N2'-去乙?；?N2'-(4-巰基-4-甲基-1-氧代戊基)-6-甲基美登素
| 中文名稱 | N2'-去乙?；?N2'-(4-巰基-4-甲基-1-氧代戊基)-6-甲基美登素 |
|---|---|
| 中文同義詞 | N2'-去乙酰基-N2'-(4-巰基-4-甲基-1-氧代戊基)-6-甲基美登素;英文名稱:MAYTANSINOID DM4;化合物 T13766;美坦新雜質1;化合物 MAYTANSINOID DM4 |
| 英文名稱 | Maytansinoid dM4 |
| 英文同義詞 | Maytansinoid dM4;N2'-deacetyl-n2'-(4-Mercapto-4-Methyl-1-oxopentyl)-6-MethylMaytansine;Maytansine, N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-6-methyl-;Maytansinoid DM4,Maytansinoid DM-4;N2'-Deacyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-6-methylmaytansine |
| CAS號 | 799840-96-3 |
| 分子式 | C39H56ClN3O10S |
| 分子量 | 794.4 |
| EINECS號 | |
| 相關類別 | 醫(yī)藥原料藥;醫(yī)用原料;原料藥;醫(yī)藥原料;化學試劑 |
| Mol文件 | 799840-96-3.mol |
| 結構式 |  |
N2'-去乙酰基-N2'-(4-巰基-4-甲基-1-氧代戊基)-6-甲基美登素 性質
| 沸點 | 940.2±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.28±0.1 g/cm3(Predicted) |
| 酸度系數(shù)(pKa) | 9.83±0.70(Predicted) |
Maytansinoid DM4 是一種具有強力細胞毒性的含硫醇美登素衍生物，可用作 ADC 的細胞毒性部分。
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Maytansinoids
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Maytansine is a natural benzoansamacrolide product isolated from the bark of the African shrub Maytenus ovatus . Maytansine binds to the same site on tubulin as the vinca alkaloids, with similar in vitro inhibition constants, but is a more-potent cytotoxin.