| | 48208-26-0 Basic information More.. |
| Product Name: | RG108 | | Synonyms: | (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid;RG108/RG-108;(S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;N-Phthaloyl-L-tryptophan;1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (αS)-;N-Phthaloyl-L-tryptophan
(S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;DNA Methyltransferase Inhibitor;N-Phthalyl-L-tryptophan | | CAS: | 48208-26-0 | | MF: | C19H14N2O4 | | MW: | 334.33 | | EINECS: | | | Mol File: | 48208-26-0.mol |  |
Use
DNA methylation regulates gene expression in normal and malignant cells. RG-108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro). It significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine. Further, RG-108 inhibits DNA methyltransferase activity by blocking the enzyme active site. Through these actions, RG-108 demethylates and reactivates epigenetically silenced tumor suppressor genes.
- RG108
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- US $39.00-119.00 / mg
- 2024-11-19
- CAS:48208-26-0
- Min. Order:
- Purity: 99.78%
- Supply Ability: 10g
- RG108/RG-108
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- US $1.00 / KG
- 2019-09-06
- CAS:48208-26-0
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 20kg
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48208-26-0
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