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ChemicalBook >> CAS DataBase List >> 1,4-Dioxane

1,4-Dioxane

1,4-Dioxane price.
  • $20 - $26160
  • Product name: 1,4-Dioxane
  • CAS: 123-91-1
  • MF: C4H8O2
  • MW: 88.11
  • EINECS:204-661-8
  • MDL Number:MFCD00006571
  • Synonyms:1,4-Dioxin, tetrahydro-;1,4-dioxin,tetrahydro ;dioxyethyleneether ;DuPont zonyl FSO-100 fluorinated surfactants;Ethylene glycol ethylene ether;Ethyleneether ;Glycol ethylene ether;Glycol ethylene ether 8
79 prices
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  • AK Scientific
  • American Custom Chemicals Corporation
  • Biosynth Carbosynth
  • GFS CHEMICALS
  • Medical Isotopes, Inc.
  • Oakwood
  • Sigma-Aldrich
  • SynQuest Laboratories
  • TCI Chemical
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  • ManufacturerAK Scientific
  • Product number9042AF
  • Product description1,4-Dioxane
  • Packaging100mL
  • Price$22
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM0017321
  • Product descriptionDIOXANE 1,4 95.00%
  • Packaging25G
  • Price$1106.03
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM0017321
  • Product descriptionDIOXANE 1,4 95.00%
  • Packaging500G
  • Price$4263.3
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberFD11425
  • Product description1,4-Dioxane
  • Packaging1kg
  • Price$40
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberFD11425
  • Product description1,4-Dioxane
  • Packaging2Kg
  • Price$70
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberFD11425
  • Product description1,4-Dioxane
  • Packaging5kg
  • Price$155
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberFD11425
  • Product description1,4-Dioxane
  • Packaging10Kg
  • Price$280
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberFD11425
  • Product description1,4-Dioxane
  • Packaging25kg
  • Price$650
  • Updated2021-12-16
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  • ManufacturerGFS CHEMICALS
  • Product number34952
  • Product descriptionDIOXANE,REAGENT(ACS)
  • Packaging4L
  • Price$162.55
  • Updated2021-12-16
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  • ManufacturerMedical Isotopes, Inc.
  • Product number16593
  • Product description1,4-DIOXANE,ANHYDROSOLVGRADE
  • Packaging100mL
  • Price$580
  • Updated2021-12-16
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  • ManufacturerOakwood
  • Product number044719
  • Product description1,4-Dioxane 99.0%
  • Packaging1Kg
  • Price$36
  • Updated2021-12-16
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  • ManufacturerSigma-Aldrich
  • Product numberPHR1549
  • Product description1,4-Dioxane Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging3x1.2ml
  • Price$114
  • Updated2025-07-31
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  • ManufacturerSigma-Aldrich
  • Product number76887
  • Product description1,4-Dioxane analytical standard
  • Packaging10ml-f
  • Price$95.9
  • Updated2021-12-16
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  • ManufacturerSigma-Aldrich
  • Product number900640
  • Product description1,4-Dioxane anhydrous, ZerO2 , 99.8%
  • Packaging4x2ml
  • Price$163.35
  • Updated2025-07-31
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  • ManufacturerSigma-Aldrich
  • Product numberRTC000093
  • Product description1,4-Dioxane Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging20ml
  • Price$159
  • Updated2025-07-31
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  • ManufacturerSigma-Aldrich
  • Product number612111
  • Product description1,4-Dioxane solution NMR reference standard, 40% in benzene-d6 (99.6 atom % D), NMR tube size 3 mm × 8 in.
  • Packaging1ea
  • Price$214
  • Updated2022-05-15
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9042AF 1,4-Dioxane 100mL $22 2021-12-16 Buy
American Custom Chemicals Corporation CHM0017321 DIOXANE 1,4 95.00% 25G $1106.03 2021-12-16 Buy
American Custom Chemicals Corporation CHM0017321 DIOXANE 1,4 95.00% 500G $4263.3 2021-12-16 Buy
Biosynth Carbosynth FD11425 1,4-Dioxane 1kg $40 2021-12-16 Buy
Biosynth Carbosynth FD11425 1,4-Dioxane 2Kg $70 2021-12-16 Buy
Biosynth Carbosynth FD11425 1,4-Dioxane 5kg $155 2021-12-16 Buy
Biosynth Carbosynth FD11425 1,4-Dioxane 10Kg $280 2021-12-16 Buy
Biosynth Carbosynth FD11425 1,4-Dioxane 25kg $650 2021-12-16 Buy
GFS CHEMICALS 34952 DIOXANE,REAGENT(ACS) 4L $162.55 2021-12-16 Buy
Medical Isotopes, Inc. 16593 1,4-DIOXANE,ANHYDROSOLVGRADE 100mL $580 2021-12-16 Buy
Oakwood 044719 1,4-Dioxane 99.0% 1Kg $36 2021-12-16 Buy
Sigma-Aldrich PHR1549 1,4-Dioxane Pharmaceutical Secondary Standard; Certified Reference Material 3x1.2ml $114 2025-07-31 Buy
Sigma-Aldrich 76887 1,4-Dioxane analytical standard 10ml-f $95.9 2021-12-16 Buy
Sigma-Aldrich 900640 1,4-Dioxane anhydrous, ZerO2 , 99.8% 4x2ml $163.35 2025-07-31 Buy
Sigma-Aldrich RTC000093 1,4-Dioxane Pharmaceutical Secondary Standard; Certified Reference Material 20ml $159 2025-07-31 Buy
Sigma-Aldrich 612111 1,4-Dioxane solution NMR reference standard, 40% in benzene-d6 (99.6 atom % D), NMR tube size 3 mm × 8 in. 1ea $214 2022-05-15 Buy

Properties

Melting point :12 °C
Boiling point :101 °C
Density :1.034 g/mL at 25 °C(lit.)
vapor density :3 (vs air)
vapor pressure :27 mm Hg ( 20 °C)
refractive index :n20/D 1.422(lit.)
Flash point :54 °F
storage temp. :room temp
solubility :Soluble in acetone, alcohol, benzene, and ether (Weast, 1986). Miscible with most organic solvents (Huntress and Mulliken, 1941) including 2-methylpropanol, toluene, cychexanone, and cyclopentanone.
form :Solution
color :APHA: ≤20
PH :6-8 (500g/l, H2O, 20℃)
Odor :Mild ether-like odor detectable at 0.8 to 172 ppm (mean = 12 ppm)
explosive limit :1.7-25.2%(V)
Water Solubility :SOLUBLE
Sensitive :Hygroscopic
λmax :λ: 220 nm Amax: ≤0.70
λ: 235 nm Amax: ≤0.50
λ: 250 nm Amax: ≤0.20
λ: 270 nm Amax: ≤0.10
λ: 295-400 nm Amax: ≤0.01 Merck :14,3300
BRN :102551
Henry's Law Constant :4.89(x 10-6 atm?m3/mol) (static headspace-GC, Welke et al., 1998)
Dielectric constant :2.2(25℃)
Exposure limits :TLV-TWA 25 ppm (≈90 mg/m3) (ACGIH), 100 ppm (MSHA and OSHA); carcinogenicity: Animal Sufficient Evidence (IARC).
Stability :Stable. Incompatible with oxidizing agents, oxygen, halogens, reducing agents, moisture. Highly flammable - note wide explosive range. May form explosive peroxides in storage (rate of formation increased by heating, evaporation or exposure to light).
InChIKey :RYHBNJHYFVUHQT-UHFFFAOYSA-N
LogP :-0.42 at 20℃
Surface tension :32.71mN/m at 293.15K
CAS DataBase Reference :123-91-1(CAS DataBase Reference)
IARC :2B (Vol. 11, Sup 7, 71) 1999
NIST Chemistry Reference :1,4-Dioxane(123-91-1)
EPA Substance Registry System :1,4-Dioxane (123-91-1)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H304 May be fatal if swallowed and enters airways Aspiration hazard Category 1 Danger GHS hazard pictograms
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger GHS hazard pictograms
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P273 Avoid release to the environment.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P331 Do NOT induce vomiting.

Description

1,4-Dioxane is a hexahydroxy heterocyclic compound containing two oxygen heteroatoms. molecular formula C4H8O2,a colorless, flammable liquid, slight ether smell, photosensitive. Its Vapor can easily form explosive peroxides by absorbing oxygen in the air. Explosion limit 1.97%-1.97% (volume), It should be disposed by reducing agent in distillation process. Melting point 11.8 ℃, boiling point of 101 ℃ (750 mmHg), density 1.0337 (20/4 ℃), refractive index 1.4224, flash point12℃. Soluble in water, ethanol, ether and other organic solvents. It can form azeotrope with water (water content 18.6%) and the boiling point is 87.8 ℃. It turns bright yellow when reacting with tetranitromethane. Trace amount of 2,6-Di-tert-butyl-4-methylphenol(BHT) is often added to the commodity as a stabilizer. Low toxicity, half lethal dose (rats, oral) 4200 mg/kg. A possible carcinogen, an irritating chemical. 1,4-Dioxane can be prepared by dehydration of ethylene glycol by sulfuric acid and it is the indirect product in the production of epoxy ethane. As a good organic solvent, it has a wide application such as the solvent for cellulose acetate and lots of resins. It Is mainly used in the pharmaceutical industry as extraction agent, as a stabilizer in the production of 1,1,1 – trichloroethane as a volatile solvent in the production of polyurethane in place of dimethylformamide and tetrahydrofuran, as stripping agent in the crafts of coating and painting, as a solvent and dispersant in the dye industry, as a stabilizer in printing ink, and also as treatment agent for metal surface. In addition , it can also be used in cosmetics, spices manufacture, electroplating, etc.

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