| Identification | More | [Name]
(S)-2-(Aminomethyl)-1-Cbz-pyrrolidine | [CAS]
119020-03-0 | [Synonyms]
1-CBZ-2-AMINOMETHYL PYRROLIDINE
1-CBZ-4-AMINOMETHYLPIPERIDINE
1-N-CBZ-2-(AMINOMETHYL)PYRROLIDINE
(+/-)-2-(AMINOMETHYL)-1-N-CBZ-PYYROLIDINE
2-AMINOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER
4-AMINOMETHYL-1-N-CBZ-PIPERIDINE
4-AMINOMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
4-(AMINOMETHYL)PIPERIDINE, N-CBZ PROTECTED
BENZYL 4-(AMINOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
BUTTPARK 93\50-51
N-CBZ-4-AMINOMETHYLPIPERIDINE
(S)-1-CBZ-2-AMINOMETHYLPYRROLIDINE
(S)-1-N-CBZ-2-(AMINOMETHYL)PYRROLIDINE
(S)-2-(Aminomethyl)-1-Cbz-pyrrolidine
(S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE
(S)-2-AMINOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER
(S)-BENZYL-2-(AMINOMETHYL)PYRROLIDINE-1-CARBOXYLATE | [Molecular Formula]
C13H18N2O2 | [MDL Number]
MFCD03001690 | [Molecular Weight]
234.29 | [MOL File]
119020-03-0.mol |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P305+P351+P338 | [Hazard Codes ]
Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . |
| Hazard Information | Back Directory | [Uses]
(S)-Benzyl 2-(aminomethyl)pyrrolidine-1-carboxylate was a useful reagent in preparation of trifluoro-N-[(S)-pyrrolidinylmethyl]methanesulfonamide. | [Synthesis]
GENERAL METHOD: Under stirring conditions, azide derivatives 9a or 9b (4.03 mmol) were dissolved in THF (1 mL), followed by the addition of solid triphenylphosphine (Ph3P, 4.03 mmol) and water (H2O, 6.04 mmol). The reaction mixture was stirred continuously for 12 h at room temperature. After completion of the reaction, the solvent was removed by concentration under reduced pressure. The crude product was purified by rapid column chromatography on silica gel with the eluent being a solvent mixture of methanol-dichloromethane (9:1, v/v). | [References]
[1] Synthetic Communications, 2011, vol. 41, # 17, p. 2517 - 2523
[2] Synthesis (Germany), 2013, vol. 45, # 17, p. 2458 - 2468
[3] Tetrahedron Letters, 2010, vol. 51, # 1, p. 209 - 212
[4] Tetrahedron Letters, 1991, vol. 32, # 49, p. 7183 - 7186 |
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