トリホスアデニン二ナトリウム 化學(xué)特性,用途語(yǔ),生産方法
定義
本品は、アデノシン三リン酸(*)の二ナトリウム塩である。參照表示名稱(chēng)：アデノシン三リン酸
化粧品の成分用途
皮膚コンディショニング剤
効能
鎮(zhèn)暈薬, 代謝賦活薬
商品名
ATP (アルフレッサファーマ); ATP (第一三共); アデホス (興和); アデホス (興和); アデホス?L (興和); トリノシン (トーアエイヨー); トリノシン (トーアエイヨー); トリノシン (トーアエイヨー)
説明
ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is an organic sodium salt. It consists of an ATP and a ({(2R,3S,4R,5R)-3,4-dihydroxy-5-(9h -purin-9-yl)oxolan-2-yl)methylphosphonatooxy)phosphonate. It has the role of providing a source of energy for cells and is a central component of energy storage and metabolism in the body. ATP disodium salt is an important endogenous signalling molecule in immunity and inflammation. It is an important component in the study of various physiological and biochemical processes. It is involved in a variety of cellular functions such as muscle contraction, nerve impulse transmission and membrane transport, making it a fundamental molecule for understanding biological mechanisms. It can also be used to photometrically determine Luc activity in cell extracts.
化學(xué)的特性
White powder
使用
A metabolite of Adenosine (A280400), a multifunctional nucleoside triphosphate used in cells as a coenzyme of intracellular energy transfer. It transports chemical energy within cells for metabolism. ATP Disodium Salt is used in the synthetic preparation of ribose-modified deoxyadenosine bisphosphate analogues as P2Y1 receptor ligands.
生物活性
P2 purinoceptor agonist.
in vitro
ATP disodium salt (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on activating the NLRP3 inflammasome in HGFs.
ATP disodium salt (2 mM; 0.5-24 hours) induces the secretion of interleukin 1β, KC, and MIP-2 from bone marrow-derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner.
ATP disodium salt stimulates cytokine and chemokine secretion, and inflammasome activation, directly and indirectly, induces in vitro neutrophil chemotaxis.
Toxicity evaluation
ATP disodium salt was administered by gavage to rats for 90 consecutive days at doses of 0 (control), 500, 1000, and 2000 mg kg BW?1·d?1 (n = 10 per sex/group). Subchronic administration of ATP was well tolerated at all dose levels. Body weights and feed consumption body weight gains were similar between ATP-treated and control rats. Minor differences were seen in hematology and blood chemistry; however, these changes were not dose-related and, therefore, not of biological or toxicological significance. Only one difference was observed in absolute organ weights; females of the high dose had increased kidney and increased relative kidney and liver weights; however, these differences were not seen in males nor appeared to be dose-related[1].
トリホスアデニン二ナトリウム 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品