ChemicalBook >> CAS DataBase List >>Ethyl 2-chloroacetoacetate
Ethyl 2-chloroacetoacetate
- CAS No.
- 609-15-4
- Chemical Name:
- Ethyl 2-chloroacetoacetate
- Synonyms
- Ethyl 2-chloro-3-oxobutanoate;2-chloroacetoacetate;2-CHLORACETYLETHYL ACETATE;2-Chloro-3-oxobutanoic acid, ethyl ester;Butanoic acid, 2-chloro-3-oxo-, ethyl ester;A 21960;2-CL-ACE;AKOS BBS-00004302;Ethyl 2-chloroacetoa;2-Chloroacylacidester
- CBNumber:
- CB9396009
- Molecular Formula:
- C6H9ClO3
- Molecular Weight:
- 164.59
- MDL Number:
- MFCD00009141
- MOL File:
- 609-15-4.mol
- MSDS File:
- SDS
Last updated:2025-04-29 17:45:46
| Melting point | -80 °C |
|---|---|
| Boiling point | 107 °C/14 mmHg (lit.) |
| Density | 1.19 g/mL at 25 °C (lit.) |
| vapor pressure | 49.4-100Pa at 20℃ |
| refractive index |
n |
| Flash point | 122 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) |
| form | Liquid |
| pka | 7.92±0.46(Predicted) |
| color | Clear yellow |
| Water Solubility | 17 g/L (20 ºC) |
| BRN | 774278 |
| LogP | 1.2 at 20℃ and pH1-7 |
| Surface tension | 69.4mN/m at 1g/L and 20℃ |
| CAS DataBase Reference | 609-15-4(CAS DataBase Reference) |
| FDA UNII | A9GFN94N9A |
| NIST Chemistry Reference | Butanoic acid, 2-chloro-3-oxo-, ethyl ester(609-15-4) |
| EPA Substance Registry System | Ethyl 2-chloroacetoacetate (609-15-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H319-H335-H226-H302-H314 | |||||||||
| Precautionary statements | P210-P233-P240-P241+P242+P243-P260-P264-P270-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405-P501-P280-P305+P351+P338-P310-P261-P303+P361+P353-P501a | |||||||||
| Hazard Codes | C,Xn,F | |||||||||
| Risk Statements | 10-22-34-52/53-36/37/38-36 | |||||||||
| Safety Statements | 16-26-36/37/39-45-61-37/39 | |||||||||
| RIDADR | UN 2920 8/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| F | 19 | |||||||||
| Hazard Note | Corrosive | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3.2 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29183000 | |||||||||
| NFPA 704 |
|
Ethyl 2-chloroacetoacetate price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C1218 | Ethyl 2-Chloroacetoacetate >95.0%(GC) | 609-15-4 | 25g | $22 | 2025-07-31 | Buy |
| TCI Chemical | C1218 | Ethyl 2-Chloroacetoacetate >95.0%(GC) | 609-15-4 | 500g | $161 | 2025-07-31 | Buy |
| Sigma-Aldrich | E16902 | Ethyl 2-chloroacetoacetate 95% | 609-15-4 | 500g | $87 | 2022-05-15 | Buy |
| TRC | E903485 | Ethyl2-Chloracetoacetate | 609-15-4 | 50g | $120 | 2021-12-16 | Buy |
| TRC | E903485 | Ethyl2-Chloracetoacetate | 609-15-4 | 250g | $275 | 2021-12-16 | Buy |
Ethyl 2-chloroacetoacetate Chemical Properties,Uses,Production
Chemical Properties
clear bright yellow liquid
Uses
Ethyl 2-chloroacetoacetate was used to study reductive dechlorination of β-keto ester ethyl 2-chloroacetoacetate by Saccharomyces cerevisiae.
Biochem/physiol Actions
Ethyl 2-chloroacetoacetate reacts with thiosemicarbazones to form heterocyclic substituted thiophene derivatives having non-steroidal anti-inflammatory activity.
Synthesis
Using ethyl acetoacetate and thionyl chloride as raw materials, the condensation reaction is carried out in the presence of a solvent. The dosage ratio of ethyl acetoacetate, thionyl chloride, and solvent is 1:1.37~2.75:2.31~4.62 by mass, the temperature of the condensation reaction is 75~95°C, and the reaction time is 5.5-9h. After stopping the reaction, evaporate most of the solvent and unreacted thionyl chloride under normal pressure, and then distill the remaining organic phase under reduced pressure to collect the 107-108°C/1.87kPa fraction to obtain Ethyl 2-chloroacetoacetate Products. The solvents used were n-heptane or, dichloroethane or toluene.
Ethyl 2-chloroacetoacetate Preparation Products And Raw materials
Raw materials
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Preparation Products
2,4-Dimethylthiazole-5-carboxylic acid
4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID
4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
ETHYL 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLATE
4-METHYLOXAZOLE-5-CARBONYL CHLORIDE
1of3
Global( 547)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5251 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 8982 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21622 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2988 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
View Lastest Price from Ethyl 2-chloroacetoacetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-03 | Ethyl 2-chloroacetoacetate
609-15-4
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2025-06-24 | Ethyl 2-chloroacetoacetate
609-15-4
|
US $1.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-05-26 | Ethyl 2-chloroacetoacetate
609-15-4
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- Ethyl 2-chloroacetoacetate
609-15-4
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Ethyl 2-chloroacetoacetate
609-15-4
- US $1.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Ethyl 2-chloroacetoacetate
609-15-4
- US $5.00-2.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
609-15-4(Ethyl 2-chloroacetoacetate)Related Search:
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A-CHLOROACETOACETIC ESTER
AKOS BBS-00004302
2-CHLOROACETOACETIC ACID ETHYL ESTER
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Oxiracetam Impurity 12
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Ethyl 2-Chloroacetoacetate >
Ethyl 2-chloroacetoacetateEthyl 2-chloroacetoacetate
Ethyl 2-chloro-3-oxobutanoate
2-Chloro-3-oxobutanoic acid, ethyl ester
2-chloroacetoacetate
2-CHLORACETYLETHYL ACETATE
Butanoic acid, 2-chloro-3-oxo-, ethyl ester
Ethyl 2-chloroacetoacetate (or)
Ethyl 2-oxo-3-piperidinecarboxylate
Apixaban Impurity SM3-1（Apixaban Impurity 3）
2-chloro ethyl aceto acetate
2-Chloroacetoacetate ethyl ester
2-Chloroacylacidester
609-15-4
KETONE
Esters
Organic Building Blocks
Building Blocks
C6 to C7
Carbonyl Compounds
Organic synthesis
Aliphatics
C6 to C7