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ChemicalBook >> CAS DataBase List >>Efaproxiral

Efaproxiral

CAS No.
131179-95-8
Chemical Name:
Efaproxiral
Synonyms
Efaproxyn;faproxiral;Efaproxiral;EFAPROXIRALUM;Efaproxiral (RSR13);Efaproxiral free acid;EFAPROXIRAL;EFAPROXIRAL FREE ACID;FAPROXIRAL;2-[4-(3,5-Dimethylphenylcarbamoylmethyl)phenoxy]-2-methylpropionic acid;2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid;Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-
CBNumber:
CB91359078
Molecular Formula:
C20H22NO4.Na
Molecular Weight:
341.4
MDL Number:
MFCD00899086
MOL File:
131179-95-8.mol
MSDS File:
SDS
Last updated:2024-10-28 16:48:35

Efaproxiral Properties

Melting point 48-50°C
Boiling point 554.5±50.0 °C(Predicted)
Density 1.202±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
pka 3.26±0.10(Predicted)
form Solid
color Off-White to Tan
FDA UNII J81E81G364
NCI Dictionary of Cancer Terms efaproxiral
NCI Drug Dictionary efaproxiral
ATC code L01XD06

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

Efaproxiral price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 28294 Efaproxiral 131179-95-8 100mg $68 2024-03-01 Buy
Cayman Chemical 28294 Efaproxiral 131179-95-8 1g $535 2024-03-01 Buy
Cayman Chemical 28294 Efaproxiral 131179-95-8 250mg $161 2024-03-01 Buy
Cayman Chemical 28294 Efaproxiral 131179-95-8 500mg $302 2024-03-01 Buy
TRC E415000 Efaproxiral 131179-95-8 250mg $175 2021-12-16 Buy
Product number Packaging Price Buy
28294 100mg $68 Buy
28294 1g $535 Buy
28294 250mg $161 Buy
28294 500mg $302 Buy
E415000 250mg $175 Buy

Efaproxiral Chemical Properties,Uses,Production

Description

Efaproxiral is an allosteric hemoglobin (Hb) modifier that reduces the affinity of Hb for oxygen, increasing the diffusion of oxygen from blood to tissue. In isolated human whole blood, efaproxiral (1.75 mM) increases the partial pressure of oxygen at which Hb is 50% saturated (p50) from 26.75 to 38.63 mm Hg and decreases the percent oxyhemoglobin (Hb-O2) saturation from 48 to 33.8% at a partial oxygen pressure (pO2) of 26 mm Hg. Efaproxiral (150 mg/kg) increases tumor pO2 from 5.2 to 13.1 mm Hg 30 minutes after administration in a RIF-1 mouse fibrosarcoma flank tumor model. Efaproxiral (100 μM) enhances radiation-induced cytotoxicity in EMT6 mouse breast cancer cells grown under hypoxic conditions and increases radiosensitization and inhibits tumor growth in a hypoxic Lewis lung tumor mouse model when administered at a dose of 100 mg/kg. It also increases the running capacity of normal mice and mice with left coronary artery (LCA) ligation-induced myocardial infarction (MI) when administered at a dose of 150 mg/kg.

Chemical Properties

Off-White to Tan Solid

Uses

Allosteric modifier of hemoglobin (HB). Binds in the central water cavity of the Hb molecule causing a conformational change such that bound oxygen is released more readily. Antineoplastic adjunct (radiosensitizer).

156-38-7
131179-95-8
Synthesis of Efaproxiral from 4-Hydroxyphenylacetic acid
Global( 75)Suppliers
Supplier Tel Email Country ProdList Advantage
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6383 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29808 58
SIMAGCHEM CORP 		+86-13806087780 sale@simagchem.com China 17365 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58

View Lastest Price from Efaproxiral manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Efaproxiral pictures 2024-10-28 Efaproxiral
131179-95-8
 US $30.00-83.00 / mg 10g TargetMol Chemicals Inc.
Efaproxiral pictures 2020-01-05 Efaproxiral
131179-95-8
 US $1.00 / KG 1KG 95--99% 1ton Career Henan Chemical Co
  • Efaproxiral pictures
  • Efaproxiral
    131179-95-8
  • US $30.00-83.00 / mg
  • TargetMol Chemicals Inc.
  • Efaproxiral pictures
  • Efaproxiral
    131179-95-8
  • US $1.00 / KG
  • 95--99%
  • Career Henan Chemical Co
2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid Efaproxiral Efaproxiral free acid faproxiral EFAPROXIRALUM 2-[4-(3,5-Dimethylphenylcarbamoylmethyl)phenoxy]-2-methylpropionic acid EFAPROXIRAL;EFAPROXIRAL FREE ACID;FAPROXIRAL Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl- Efaproxiral (RSR13) Efaproxyn 131179-95-8 C20H22NO4Na Amines Aromatics Intermediates & Fine Chemicals Pharmaceuticals