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ChemicalBook >> CAS DataBase List >>HIF-2α-IN-1

HIF-2α-IN-1

CAS No.
1799948-06-3
Chemical Name:
HIF-2α-IN-1
Synonyms
HIF-2&HIF-2α-IN-1;HIF-2 Alpha -IN-1;HIF 2α IN 1,HIF2αIN1;HIF-2α-IN-1, 10 mM in DMSO;3-[[(3R)-4-(difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxo-3H-benzothiophen-5-yl]oxy]-5-fluoro-benzonitrile;(R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxido-2,3-dihydrobenzo[b]thiophen-5-yl)oxy)-5-fluorobenzonitrile;Benzonitrile, 3-[[(3R)-4-(difluoromethyl)-2,2-difluoro-2,3-dihydro-3-hydroxy-1,1-dioxidobenzo[b]thien-5-yl]oxy]-5-fluoro-
CBNumber:
CB83122343
Molecular Formula:
C16H8F5NO4S
Molecular Weight:
405.3
MDL Number:
MFCD29924741
MOL File:
1799948-06-3.mol
Last updated:2025-04-17 18:22:24

HIF-2α-IN-1 Properties

Boiling point 499.8±45.0 °C(Predicted)
Density 1.70±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
pka 9.52±0.40(Predicted)
color White to light yellow

HIF-2α-IN-1 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-5544 HIF-2α-IN-1 99.92% 1799948-06-3 5mg $520 2021-12-16 Buy
ChemScene CS-5544 HIF-2α-IN-1 99.92% 1799948-06-3 10mg $880 2021-12-16 Buy
Crysdot CD31002918 HIF-2α-IN-1 98+% 1799948-06-3 50mg $1042 2021-12-16 Buy
Crysdot CD31002918 HIF-2α-IN-1 98+% 1799948-06-3 100mg $1459 2021-12-16 Buy
DC Chemicals DC23091 HIF2α-IN-1 >98% 1799948-06-3 10mg $800 2021-12-16 Buy
Product number Packaging Price Buy
CS-5544 5mg $520 Buy
CS-5544 10mg $880 Buy
CD31002918 50mg $1042 Buy
CD31002918 100mg $1459 Buy
DC23091 10mg $800 Buy

HIF-2α-IN-1 Chemical Properties,Uses,Production

Uses

HIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500 nM in HIF-2α scintillation proximity assay. IC50 value: ＜ 500 nM Target: HIF-2α

References

[1] Bruick Richard Keith, et al. HIF-2α inhibitors for treating iron overload disorders. From PCT Int. Appl. (2016), WO 2016057242 A1 20160414.
[2] Dixon Darryl David, et al. Preparation of cyclic sulfone and sulfoximine analogs as HIF-2α inhibitors. From PCT Int. Appl. (2015), WO 2015095048 A1 20150625.

HIF-2α-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

HIF-2α-IN-1 Suppliers

Global( 34)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323658 +86-18168183658 sales1@artkmedchem.com China 39002 58
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3466 58
Musechem +1-800-259-7612 info@musechem.com United States 4660 60
Yujinpharma(Tianjin) Technology Co.,Ltd. 13370351217 kungfu1217@1 kungfu1217@163.com China 8976 58
HIF-2α-IN-1 HIF-2& HIF-2 Alpha -IN-1 Benzonitrile, 3-[[(3R)-4-(difluoromethyl)-2,2-difluoro-2,3-dihydro-3-hydroxy-1,1-dioxidobenzo[b]thien-5-yl]oxy]-5-fluoro- (R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxido-2,3-dihydrobenzo[b]thiophen-5-yl)oxy)-5-fluorobenzonitrile 3-[[(3R)-4-(difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxo-3H-benzothiophen-5-yl]oxy]-5-fluoro-benzonitrile HIF 2α IN 1,HIF2αIN1 HIF-2α-IN-1, 10 mM in DMSO 1799948-06-3 C16H8F5NO4S