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ChemicalBook >> CAS DataBase List >>NDI-010976

NDI-010976

CAS No.
1434635-54-7
Chemical Name:
NDI-010976
Synonyms
N-654;ND-630;GS0976;CS-2609;CS-2632;CPDB5078;EOS-61252;NDI-010976;Firsocostat;GS0976,ND-630
CBNumber:
CB73133386
Molecular Formula:
C28H31N3O8S
Molecular Weight:
569.63
MDL Number:
MFCD28963986
MOL File:
1434635-54-7.mol
Last updated:2025-04-17 18:22:24

NDI-010976 Properties

Boiling point 779.0±70.0 °C(Predicted)
Density 1.42±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:75.0(Max Conc. mg/mL);131.66(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);17.56(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);5.27(Max Conc. mM)
form A crystalline solid
pka 3.66±0.10(Predicted)
color White to light yellow
FDA UNII XE10NJQ95M

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280-P305+P351+P338

NDI-010976 price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 23961 ND-630 ≥98% 1434635-54-7 1mg $364 2024-03-01 Buy
Cayman Chemical 23961 ND-630 ≥98% 1434635-54-7 5mg $1181 2024-03-01 Buy
AK Scientific 9222DU Firsocostat 1434635-54-7 5mg $1412 2021-12-16 Buy
ChemScene CS-6509 Firsocostat 99.48% 1434635-54-7 10mg $450 2021-12-16 Buy
American Custom Chemicals Corporation INB0005695 (R)-2-(1-(2-(2-METHOXYPHENYL)-2-((TETRAHYDRO-2H-PYRAN-4-YL)OXY)ETHYL)-5-METHYL-6-(OXAZOL-2-YL)-2,4-DIOXO-1,2-DIHYDROTHIENO[2,3-D]PYRIMIDIN-3(4H)-YL)-2-METHYLPROPANOIC ACID 95.00% 1434635-54-7 5MG $497.67 2021-12-16 Buy
Product number Packaging Price Buy
23961 1mg $364 Buy
23961 5mg $1181 Buy
9222DU 5mg $1412 Buy
CS-6509 10mg $450 Buy
INB0005695 5MG $497.67 Buy

NDI-010976 Chemical Properties,Uses,Production

Description

ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC50s = 2.1 and 6.1 nM, respectively, for the human enzymes). It is selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 μM. ND-630 prevents dimerization of ACC by interacting within the phosphopeptide-acceptor and dimerization site. It reduces fatty acid synthesis (EC50s = 66 and 9 nM in 10% FBS and serum-free media, respectively) and increases fatty acid oxidation in HepG2 cells. ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.

Uses

Firsocostat or ND-630 (CAS# 1434635-54-7) is an inhibitor of acetyl-coA carboxylase and may favorably affect the morbidity and mortality associated with obesity, diabetes, and fatty liver disease from reduced hepatic steatosis, improved insulin sensitivity, and modulation of dyslipidemia.

in vivo

Chronical administration of Firsocostat (ND-630) to rats with diet-induced obesity reduces hepatic steatosis, improves insulin sensitivity, reduces weight gain without affecting food intake, and favorably affects dyslipidemia. Chronical administration of Firsocostat Zucker diabetic fatty rats, Firsocostat reduces hepatic steatosis, improves glucose-stimulated insulin secretion, and reduces hemoglobin A1c (0.9% reduction). Firsocostat exhibits an aqueous solubility of 594 μM and human and rat plasma protein binding of 98.5% and 98.6%, respectively. Pharmacokinetic evaluation of Firsocostat in male Sprague-Dawley rats [i.v. 3 mg/kg; orally (p.o.) 10 mg/kg] yields a plasma t1/2 of 4.5 h, bioavailability of 37%, clearance of 33 mL/min/kg, volume of distribution of 1.9 L/kg, oral time of maximum plasma concentration of 0.25 h[1].

NDI-010976 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 106)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29856 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Chemia Biotechnology（Shanghai） Co., Ltd 		+8613816753574 info@chemia-pharm.com CHINA 311 58
Finetech Industry Limited 		+86-27-8746-5837 +8619945049750 info@finetechnology-ind.com China 9642 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
CR Corporation Limited 		+8613062833949 fred.wen@crcorporation.cn China 8647 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58

View Lastest Price from NDI-010976 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Firsocostat pictures 2025-05-01 Firsocostat
1434635-54-7
 US $88.00-222.00 / mg 98.46% 10g TargetMol Chemicals Inc.
NDI-010976 pictures 2022-01-14 NDI-010976
1434635-54-7
 US $0.00 / KG 1KG 97.4% 100 tons Honest Joy Holdings Limited
NDI-010976 pictures 2019-07-06 NDI-010976
1434635-54-7
 US $7.00 / KG 1KG 99% 100kG Career Henan Chemical Co
  • Firsocostat pictures
  • Firsocostat
    1434635-54-7
  • US $88.00-222.00 / mg
  • 98.46%
  • TargetMol Chemicals Inc.
  • NDI-010976 pictures
  • NDI-010976
    1434635-54-7
  • US $0.00 / KG
  • 97.4%
  • Honest Joy Holdings Limited
  • NDI-010976 pictures
  • NDI-010976
    1434635-54-7
  • US $7.00 / KG
  • 99%
  • Career Henan Chemical Co

1434635-54-7(NDI-010976)Related Search:

NDI-010976 (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoicacid ND-630 (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanoic acid EOS-61252 GS0976 CPDB5078 (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3- GS0976,ND-630 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid ND-630,NDI-010976 Firsocostat Firsocostat(ND-630,GS-0976) CS-2609 CS-2632 ND 630; ND630;GS-0976;GS 0976;GS0976;FIRSOCOSTAT Firsocostat (GS-0976,NDI-010976,ND-630) ND630;FIRSOCOSTAT Firsocostat (ND-630 Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxo- ND-630（GS0976） Firsocostat (GS-0976) ND-630|||NDI-010976|||GS-0976 Firsocostat, 10 mM in DMSO N-654 Firsocostat (GS-0976, ND-630) 1434635-54-7 API