SB 223412
- CAS No.
- 174636-32-9
- Chemical Name:
- SB 223412
- Synonyms
- CS-1123;SB 223412;Talnetant (SB 223412);Talnetant, 10 mM in DMSO;SB-223412; SB223412; SB 223412;3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;(S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide;(S)-3-Hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide;3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide
- CBNumber:
- CB71333041
- Molecular Formula:
- C25H22N2O2
- Molecular Weight:
- 382.45
- MDL Number:
- MFCD00944075
- MOL File:
- 174636-32-9.mol
- MSDS File:
- SDS
| Melting point | 125.1-126.2℃ |
|---|---|
| Boiling point | 580.4±50.0 °C(Predicted) |
| Density | 1.212±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: soluble25mg/mL, clear |
| form | powder |
| pka | 6.70±0.50(Predicted) |
| color | white to beige |
| optical activity | [α]/D -25 to -31°, c = 0.5 in methanol |
| FDA UNII | CZ3T9T146K |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SB 223412 price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1165 | Talnetant ≥98% (HPLC) | 174636-32-9 | 5mg | $146 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1165 | Talnetant ≥98% (HPLC) | 174636-32-9 | 25mg | $578 | 2024-03-01 | Buy |
| Cayman Chemical | 29699 | Talnetant | 174636-32-9 | 100mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 29699 | Talnetant | 174636-32-9 | 500mg | $317 | 2024-03-01 | Buy |
| Cayman Chemical | 29699 | Talnetant | 174636-32-9 | 250mg | $169 | 2024-03-01 | Buy |
SB 223412 Chemical Properties,Uses,Production
Description
Talnetant is an antagonist of the neurokinin-3 (NK3) receptor (Ki = 1 nM). It is selective for NK3 over NK1 and NK2 receptors (Kis = 144 and >100,000 nM, respectively, in CHO cells expressing recombinant human receptors). Talnetant inhibits calcium mobilization induced by neurokinin B in HEK293 cells expressing human NK3 receptors (IC50 = 16.6 nM). It inhibits contractions induced by the NK3 receptor agonist senktide in isolated rabbit iris sphincter muscle (pD2 = 9.1). Talnetant (5-20 mg/kg) reduces senktide-induced head shakes and tail whips in mice. It also inhibits senktide-induced wet-dog shakes, increases extracellular dopamine and norepinephrine in the medial prefrontal cortex, and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs.
Uses
Talnetant acts as a neurokinin 3 (NK3) receptor antagonist used as an antispychotic.
in vivo
Talnetant (SB 223412) (0.5-2 mg/kg i.v., 2 min pretreatment) can inhibit the miosis induced by senktide (25 μg, i.v.) in a dose-dependent manner with an ED50 of 0.44mg/kg in conscious rabbits[1].
Talnetant (SB 223412) (i.p., 1-100 mg/kg, 1 h) can significantly attenuate senktide-induced "wet dog wagging" behavior in a dose-dependent manner, significantly increase extracellular dopamine and norepinephrine in the medial prefrontal cortex and reduce haloperidol-induced increases in dopamine levels in the vomeronasal nucleus of freely moving guinea pigs[3].
| Animal Model: | Male Dunkin-Hartley guinea pig[3] |
| Dosage: | 1, 3, 10, 30 or 100?mg/kg |
| Administration: | Intraperitoneal injection; 1 h |
| Result: | Showed a significant attenuation of wet dog shake (WDS) behavior from 31.1 to 16.7 at 30 mg/kg. Significantly increased extracellular DA levels to 238% and NE levels to 227.1%, without affecting 5-HT levels. |
IC 50
NK3
SB 223412 Preparation Products And Raw materials
SB 223412 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32274 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38664 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
