1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one
- CAS No.
- 188116-07-6
- Chemical Name:
- 1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one
- Synonyms
- CS-1057;ELB-138;Imepitoin;AWD 131-13;AWD 131-138, >=98%;IMEPITOIN; AWD131-138;AWD 131-138(Imepitoin);Imepitoin, 10 mM in DMSO;3-(4-chlorophenyl)-5-morpholin-4-yl-4H-imidazol-2-one;1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one
- CBNumber:
- CB71260929
- Molecular Formula:
- C13H14ClN3O2
- Molecular Weight:
- 279.72
- MDL Number:
- MFCD18450225
- MOL File:
- 188116-07-6.mol
| Melting point | 264℃ (ethanol ) |
|---|---|
| Boiling point | 421.8±55.0 °C(Predicted) |
| Density | 1.42±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility |
DMF:10.0(Max Conc. mg/mL);35.75(Max Conc. mM) DMSO:17.5(Max Conc. mg/mL);62.56(Max Conc. mM) DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.79(Max Conc. mM) Ethanol:1.13(Max Conc. mg/mL);4.02(Max Conc. mM) |
| form | A crystalline solid |
| pka | 4.39±0.20(Predicted) |
| color | White to off-white |
| FDA UNII | 19V39682LI |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361d |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3361 | Imepitoin ≥98% (HPLC) | 188116-07-6 | 10MG | $92.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3361 | Imepitoin ≥98% (HPLC) | 188116-07-6 | 50MG | $374 | 2024-03-01 | Buy |
| Cayman Chemical | 16235 | AWD 131-138 ≥98% | 188116-07-6 | 5mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 16235 | AWD 131-138 ≥98% | 188116-07-6 | 10mg | $198 | 2024-03-01 | Buy |
| Cayman Chemical | 16235 | AWD 131-138 ≥98% | 188116-07-6 | 25mg | $467 | 2024-03-01 | Buy |
1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one Chemical Properties,Uses,Production
Uses
1-(4-Chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one is used in treating feline epilepsy.
Biological Activity
Imepitoin (AWD 131-138; ELB 138) is a g-aminobutyric acid A (GABAA) receptor partial positive allosteric modulator (PAM) th at targets the benzodiazepine (BZD)-binding site at the α/γ2-interface. Imepitoin enhances GABA current (% response/[GABA] alone in μM/receptor complex = 320/3/α1β2γ2, 310/25/α1β3γ2, 460/8/α2β2γ2, 590/12/α3β2γ2 and 290/3/α5β2γ2 using Xenopus oocytes expressing respective r at receptor complex) with ~2% the potency and 17-27% the efficacy of diazepam toward α1β2γ2. Imepitoin exhibits in vivo therapeutic efficacy in animal models of seizure and epilepsy.
in vivo
AWD 131-138 did not produce midazolam-like responding or alter response rates at cumulative doses up to 18.0 mg/kg i.m. (plasma levels over 2100 ng/ml). When AWD 131-138 (10-100 microg/kg/injection) was studied by substitution, responding declined to vehicle substitution levels within three sessions. At the dose of 100 microg/kg i.v. AWD 131-138, sufficient drug was self-administered during the first session (about 3.5 mg/kg) to produce plasma levels above 1000 ng/ml, yet responding over the next two sessions dropped to vehicle levels [2]. Prolonged oral administration with twice-daily dosing of ELB 138 with either 5 or 40 mg/kg over a 5-week period was not associated with loss of anticonvulsant efficacy in the PTZ dog model [3].
1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29856 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15229 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9642 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from 1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-07 | Imepitoin
188116-07-6
|
US $48.00-172.00 / mg | 98.45% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-09-04 | 1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one
188116-07-6
|
US $5.00 / KG | 1KG | 99% | 1ton | Career Henan Chemical Co |
-
- Imepitoin
188116-07-6
- US $48.00-172.00 / mg
- 98.45%
- TargetMol Chemicals Inc.
-
- 1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one
188116-07-6
- US $5.00 / KG
- 99%
- Career Henan Chemical Co