ChemicalBook >> CAS DataBase List >>tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
- CAS No.
- 571188-59-5
- Chemical Name:
- tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
- Synonyms
- 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE;OTAVA-BB;4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester;OTAVA-BB 1207229;1-Boc-4-(6-amino-3-pyridyl)piperazine;tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate;POB02;Ribociclib-2;PALBOCICLIB4;Palbociclib-11
- CBNumber:
- CB62464781
- Molecular Formula:
- C14H22N4O2
- Molecular Weight:
- 278.35
- MDL Number:
- MFCD11594962
- MOL File:
- 571188-59-5.mol
- MSDS File:
- SDS
Last updated:2024-12-27 17:26:58
| Melting point | 130-132℃ |
|---|---|
| Boiling point | 454.1±45.0 °C(Predicted) |
| Density | 1.182 |
| vapor pressure | 0-0Pa at 20-25℃ |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Very Slightly) |
| form | Solid |
| pka | 7.36±0.26(Predicted) |
| color | Dark Yellow |
| Sensitive | Air Sensitive |
| InChI | InChI=1S/C14H22N4O2/c1-14(2,3)20-13(19)18-8-6-17(7-9-18)11-4-5-12(15)16-10-11/h4-5,10H,6-9H2,1-3H3,(H2,15,16) |
| InChIKey | RMULRXHUNOVPEI-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)N=C2)CC1 |
| LogP | 1.6-1.8 at 35℃ and pH7-9 |
| FDA UNII | 6Y3BU8W3TC |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2933599590 | |||||||||
| NFPA 704 |
|
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4669 | tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate >98.0%(HPLC)(T) | 571188-59-5 | 200mg | $66 | 2024-03-01 | Buy |
| TCI Chemical | B4669 | tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate >98.0%(HPLC)(T) | 571188-59-5 | 1g | $239 | 2024-03-01 | Buy |
| Alfa Aesar | H54315 | 4-(6-Amino-3-pyridyl)-1-Boc-piperazine, 97% | 571188-59-5 | 1g | $170.65 | 2024-03-01 | Buy |
| Alfa Aesar | H54315 | 4-(6-Amino-3-pyridyl)-1-Boc-piperazine, 97% | 571188-59-5 | 5g | $673.65 | 2024-03-01 | Buy |
| Alfa Aesar | H54315 | 4-(6-Amino-3-pyridyl)-1-Boc-piperazine, 97% | 571188-59-5 | 250mg | $57.6 | 2021-12-16 | Buy |
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Chemical Properties,Uses,Production
Physical Form
Solid
Description
Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is a pharmaceutical intermediate compound that can be used to synthesize the targeted cancer drug Ribociclib for the treatment of ER-positive and HER2-negative breast cancer.
Uses
4-(6-Amino-3-pyridyl)-1-Boc-piperazine (tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate) is used as an organic chemical synthesis intermediate.
Preparation
4- (6-Nitro-pyridin-3-yl)-piperazine-1 -carboxylic acid ie f-butyl ester and Pd/C in ethanol is stirred with an H2 balloon for 3 h. The product tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is obtained through purification.
Hazard
Causes skin irritation
Causes serious eye irritation
May cause respiratory irritation
Synthesis of tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate from 2-Aminopyridine and 1-BOC-Piperazine
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 587)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Qiwei Pharmatech Co.,Ltd | 13282840061 | mw@qwpharmatech.com | China | 109 | 58 |
| ChemExpress | +86-021-58950125 +86-021-58950125; | info@chemexpress.com | China | 785 | 58 |
| SHANDONG BOYUAN PHARMACEUTICAL CO., LTD. | +86-0531-69954981 +8615666777973 | dwyane.wang@boyuanpharm.com | China | 183 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9642 | 58 |
| Shanghai Joiny Pharmaceutical Co.,LTD | +86-13681955282 +86-13681955282 | gyd@joiny-pharma.com | China | 255 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1015 | 58 |
| ShenZhen H&D Pharmaceutical Technology Co., LTD | +8618627948422 | sale@hdimpurity.com | China | 3651 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
View Lastest Price from tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-21 | tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
571188-59-5
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-05-21 | Palbociclib side chain
571188-59-5
|
US $0.00-0.00 / Kg/Bag | 2Kg/Bag | 0.98 | 20 tons | Sinoway Industrial co., ltd. | |
 |
2025-05-16 | 4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester
571188-59-5
|
US $0.00 / Kg/Drum | 1Kg/Drum | 99% | 5000KG | Hebei Mujin Biotechnology Co.,Ltd |
-
- tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
571188-59-5
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Palbociclib side chain
571188-59-5
- US $0.00-0.00 / Kg/Bag
- 0.98
- Sinoway Industrial co., ltd.
-
- 4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester
571188-59-5
- US $0.00 / Kg/Drum
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
571188-59-5(tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate)Related Search:
6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
1-N-BOC-4-BROMOPIPERIDINE
Copper(II) chloride dihydrate
Iodomethane
sacubitril
2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-
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PD 0332991 HCl
1-Piperazinecarboxylic acid, 4-[6-[[7-cyclopentyl-6-[(diMethylaMino)carbonyl]-7H-pyrrolo[2,3-d]pyriMidin-2-yl]aMino]-3-pyridinyl]-, 1,1-diMethylethyl ester
LEE011 (succinate)
2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
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1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro-
LEE011 (hydrochloride)
1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA
1of4
1-Piperazinecarboxylic acid, 4-(6-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester
tert-butyl 4-(6-aMinopyri
4-(6-aMinopyridin-3-yl)piperazine-1-carboxylic
4-(6-AMinopyridin-3-yl)-1-Boc-piperazine
tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate(For Palbociclib)
Palbociclib's intermediate
4-(6-aMinopyridin-3-yl)p
t-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)- (acetate)
Palbociclib Intermediate
Ribociclib-2
tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate
Tert-Butyl 4-(6-Amino-3-Pyrimidin)Piperazine-1-Carboxylate
4-(6-Amino-3-pyridyl)piperazine-1-carboxylic Acid tert-Butyl Ester
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
PALBOCICLIB4
2-Methyl-2-propanyl 4-(6-amino-3-pyridinyl)-1-piperazinecarboxylate
6-(6-Aminopyridin-3-yl)piperazine, N1-BOC protected 98%
1-Butyloxycarbonyl-4-(6-aminopyridin-3-yl)-piperazine
Palbociclib Impurity 68
Palbociclib-018
Palbociclib-11
Tert-buty 4-(6-amino-3-pyridyl)piperazine-1-carboxylate
POB02
OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine
tert-butyl 4-(6-aminoyridin-3-yl)pipera-zine-1-carboxylate
OTAVA-BB 1207229
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
1-(tert-Butoxycarbonyl)-4-(6-aminopyridin-3-yl)piperazine
Palbociclib Intermediate 1, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine(571188-59-5)
4-(6-Amino-3-pyridyl)-1-Boc-piperazine
1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZIN
tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate >
4-(6-aminopyridine-3-yl) piperazine-1-carboxylic tert-butyl ester
)piperazine-1-carboxyL
Ribociclib Related Compound 1
Tert-Butyl 4-(6-aminopyridin-3-piperazine-1-carboxylate
4-(6- aminopyridine -3- yl) piperazine -1- tert-butyl carboxylate
ert-Butyl4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
1-tert-Butoxycarbonyl-4-(6-amino-3-pyridyl)piperazine
1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE
OTAVA-BB 1207229
4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester
tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate
OTAVA-BB
1-Boc-4-(6-amino-3-pyridyl)piperazine
4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Palbociclib side chain
4- (6-aminopyridine-3-yl) piperazin-1-carboxylic acid tert-butyl ester
tert-Butyl-4-(6-aminopyridin-3-yl)piperazin-1-carboxylate
571188-59-5
571188-59-9
PD 0332991
Palbociclib
Anticancer
571188-59-5