SAHO
- CAS No.
- 29907-86-6
- Chemical Name:
- SAHO
- Synonyms
- SAHO;5′-[[(3S )-3-amino-3-carboxypropyl]sulfinyl]-5′-deoxy-adenosine;Adenosine, 5'-[[(3S)-3-amino-3-carboxypropyl]sulfinyl]-5'-deoxy-;(2S)-2-Amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfinyl]butanoic acid
- CBNumber:
- CB58570995
- Molecular Formula:
- C14H20N6O6S
- Molecular Weight:
- 400.41
- MDL Number:
- MOL File:
- 29907-86-6.mol
SAHO Chemical Properties,Uses,Production
Uses
S-Adenosylhomocysteine sulfoxide is an inhibitor of catechol-O-methyltransferase (COMT) with an IC50 value of 860 μM. S-Adenosylhomocysteine sulfoxide can be used in the research of methylation reaction modulators[1].
Biological Activity
SAHO is a sulfoxide form of the methyl donor S-(5'-adenosyl)-L-methionine chloride and a substrate for radical SAM enzymes.1 It is reductively cleaved to S-adenosylhomocysteine , 5'-deoxyadenosine , and 5'-thioadenosine sulfenic acid by the radical SAM enzymes NosL or NosN.
References
1.Mandalapu, D., Ji, X., and Zhang, Q.Reductive cleavage of sulfoxide and sulfone by two radical S-adenosyl-L-methionine enzymesBiochemistry58(1)36-39(2019)
SAHO Preparation Products And Raw materials
Raw materials
Preparation Products
SAHO Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 7165 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19727 | 58 |
Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 21645 | 58 |
Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 233051 | 58 |