LHF-535
- CAS No.
- 1450929-77-7
- Chemical Name:
- LHF-535
- Synonyms
- LHF-535;LHF-535, 10 mM in DMSO;inhibit,LHF-535,Arenavirus,LHF 535,Inhibitor,LHF535;Benzenemethanol, α,α-dimethyl-4-[(1Z)-2-[1-[4-(1-methylethoxy)phenyl]-1H-benzimidazol-5-yl]ethenyl]-;Benzenemethanol, a,a-dimethyl-4-[(1Z)-2-[1-[4-(1-methylethoxy)phenyl]-1H-benzimidazol-5-yl]ethenyl]-
- CBNumber:
- CB55419769
- Molecular Formula:
- C27H28N2O2
- Molecular Weight:
- 412.53
- MDL Number:
- MFCD32062755
- MOL File:
- 1450929-77-7.mol
| Boiling point | 597.9±52.0 °C(Predicted) |
|---|---|
| Density | 1.10±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 96.67 mg/mL (234.34 mM; Need ultrasonic) |
| form | Solid |
| pka | 14.46±0.29(Predicted) |
| color | Light yellow to yellow |
| FDA UNII | BET7FM8SQG |
LHF-535 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0063343 | LHF-535 98.82% | 1450929-77-7 | 5mg | $80 | 2021-12-16 | Buy |
| ChemScene | CS-0063343 | LHF-535 98.82% | 1450929-77-7 | 10mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-0063343 | LHF-535 98.82% | 1450929-77-7 | 50mg | $350 | 2021-12-16 | Buy |
LHF-535 Chemical Properties,Uses,Production
Uses
LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively[1].
in vivo
LHF-535 (3, 10 or 30 mg/kg; orally; daily; 14 days) protectes mice from a lethal challenge with Tacaribe virus and dramatically reduces viral titers in plasma, spleen, and liver[2].
An increase in survival is also observed when the first dose of LHF-535 (10 mg/kg) is delayed by 1, 2, or 3 days after infection in mice[2].
| Animal Model: | IFN-α/β and-γ receptor-deficient AG129 mice[2] |
| Dosage: | 3, 10, or 30 mg/kg/day |
| Administration: | Orally; daily; 14 days |
| Result: | Effective as a post-exposure therapeutic. |
References
[1] Dongcheng Dai, et al. Antiviral drugs for treatment of arenavirus infection. WO2013123215A2.
[2] Madu IG, et al. A potent Lassa virus antiviral targets an arenavirus virulence determinant. PLoS Pathog. 2018 Dec 21;14(12):e1007439. DOI:10.1371/journal.ppat.1007439
LHF-535 Preparation Products And Raw materials
Raw materials
Preparation Products
LHF-535 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32284 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38668 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | 3193328036@qq.com | China | 29763 | 68 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
