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ChemicalBook >> CAS DataBase List >>4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid

4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid

CAS No.
1359963-68-0
Chemical Name:
4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid
Synonyms
S9632;FEMA 4774;EOS-60517; FEMA 4774 NEW;4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid;3-Quinolinecarboxylic acid, 4-amino-5-[2,2-dimethyl-3-[(1-methylethyl)amino]-3-oxopropoxy]-2-methyl-;4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Properties;Inhibitor,positive allosteric modulator,sucrose,weetness enhancer,FEMA-4774,T1R3,inhibit,FEMA4774,FEMA 4774,T1R2
CBNumber:
CB53142762
Molecular Formula:
C19H25N3O4
Molecular Weight:
359.42
MDL Number:
MFCD31916241
MOL File:
1359963-68-0.mol
MSDS File:
SDS
Last updated:2025-04-29 13:54:39

4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Properties

FEMA 4774 | 4-AMINO-5-(3-(ISOPROPYLAMINO)-2,2-DIMETHYL-3-OXOPROPOXY)-2-METHYLQUINOLINE-3-CARBOXYLIC ACID
storage temp. Store at -20°C
solubility DMSO : ≥ 41.67 mg/mL (115.94 mM)
form Solid
color White to off-white
Odor milky dairy
JECFA Number 2204
FDA UNII QCE6H7E9VS

4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth Carbosynth BF168573 FEMA 4774 NEW 1359963-68-0 10mg $145 2021-12-16 Buy
AK Scientific 0902DT 3-Quinolinecarboxylicacid,4-amino-5-(2,2-dimethyl-3-((1-methylethyl)amino)-3-oxopropoxy)-2-methyl- 1359963-68-0 10mg $245 2021-12-16 Buy
Biosynth Carbosynth BF168573 FEMA 4774 NEW 1359963-68-0 50mg $507.5 2021-12-16 Buy
AK Scientific 0902DT 3-Quinolinecarboxylicacid,4-amino-5-(2,2-dimethyl-3-((1-methylethyl)amino)-3-oxopropoxy)-2-methyl- 1359963-68-0 50mg $735 2021-12-16 Buy
Product number Packaging Price Buy
BF168573 10mg $145 Buy
0902DT 10mg $245 Buy
BF168573 50mg $507.5 Buy
0902DT 50mg $735 Buy

4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Chemical Properties,Uses,Production

Uses

FEMA 4774 is a positive allosteric modulator of taste receptors T1R2 and T1R3, two subunits of the human sweet taste receptor. FEMA 4774 is also used as a sucrose sweetness enhancer[1].

in vivo

FEMA 4774 (S9632) (oral gavage, 500-2000 mg/kg) does not cause a dose-dependent increase in polychromatic erythrocytes and induces micronuclei formation at dose levels up to 2000 mg/kg in Swiss albino (CD-1) mice[2].
The pharmacokinetic parameters of FEMA 4774 (S9632) in Male and Female Sprague-Dawley Rats

RouteDayDose (mg/kg)SexCmax (ng/mL)±SDTmax (hr)t1/2 (hr)AUC0last(ng?hr/mL)AUC0last/dose(ng?hr/mL/mg/kg)%F
iv11.0M2036.7±281.90.030.19330.6±58330.6-
F2625.8±679.90.030.27411.9±116.3411.9-
Oral gavage110M12.9±3.20.251.2117.9±2.31.790.54
F34.0±3.90.251.1749.2±7.84.921.19
30M90.0±23.90.330.8890.8±11.03.030.92
F62.4±25.90.421.0695.0±20.43.170.77
100M147.2±86.30.330.71176.2±73.81.760.53
F268.5±90.70.250.99341.1±81.03.410.83
Oral gavage710M16.2±3.60.500.8448.1±33.24.81-
F32.7±9.70.331.1758.9±25.45.89-
30M74.5±16.20.330.9486.0±8.72.87-
F77.1±41.70.251.39106.8±8.73.56-
100M117.9±15.30.250.72185.3±15.31.85-
F189.7±79.50.250.89278.9±79.02.79-

References

[1] Guy Servant, et al. The function and allosteric control of the human sweet taste receptor. Adv Pharmacol. 2020;88:59-82. DOI:10.1016/bs.apha.2020.01.002
[2] Amy J Arthur, et al. Toxicological evaluation of the flavour ingredient 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid. Toxicol Rep. 2015 Sep 3;2:1255-1264. DOI:10.1016/j.toxrep.2015.08.012

4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Preparation Products And Raw materials

Raw materials

Preparation Products

4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Suppliers

Global( 24)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38664 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71826 60
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62
Jinan elephant international trading co., LTD 13006575422@163.com China 6355 58
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9343 58
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 lucy@atkchemical.com China 10123 58
Shanghai zhigan biotechnology co., LTD zhiqianbio@126.com China 19778 58

View Lastest Price from 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
FEMA 4774 pictures 2025-04-29 FEMA 4774
1359963-68-0
 US $40.00-137.00 / mg 99.97% 10g TargetMol Chemicals Inc.
  • FEMA 4774 pictures
  • FEMA 4774
    1359963-68-0
  • US $40.00-137.00 / mg
  • 99.97%
  • TargetMol Chemicals Inc.

4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Spectrum

4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid EOS-60517 FEMA 4774 FEMA 4774 NEW 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Properties 3-Quinolinecarboxylic acid, 4-amino-5-[2,2-dimethyl-3-[(1-methylethyl)amino]-3-oxopropoxy]-2-methyl- S9632 Inhibitor,positive allosteric modulator,sucrose,weetness enhancer,FEMA-4774,T1R3,inhibit,FEMA4774,FEMA 4774,T1R2 1359963-68-0