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ChemicalBook >> CAS DataBase List >>Dianhydrogalactitol

Dianhydrogalactitol

CAS No.
23261-20-3
Chemical Name:
Dianhydrogalactitol
Synonyms
1,2:5,6-Dianhydrogalactitol;VAL-083;VAL083;VAL 083;NSC-132313;Dulcitol diepoxide;Dianhydrodulcitolum;Dianhydrogalactitol;5,6-Diepoxydulcitol;VAL-083, 10 mM in DMSO
CBNumber:
CB41016710
Molecular Formula:
C6H10O4
Molecular Weight:
146.14
MDL Number:
MFCD01725532
MOL File:
23261-20-3.mol
MSDS File:
SDS
Last updated:2025-04-29 17:45:46

Dianhydrogalactitol Properties

Melting point 96.5-98.5 °C
Boiling point 185.74°C (rough estimate)
Density 1.567
refractive index 1.4310 (estimate)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Powder
pka 13.53±0.20(Predicted)
color White to off-white
FDA UNII 4S465RYF7M
NCI Drug Dictionary dianhydrogalactitol
UNSPSC Code 12352200

Dianhydrogalactitol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3333 Dianhydrogalactitol ≥95% (HPLC) 23261-20-3 5MG $88.6 2024-03-01 Buy
Sigma-Aldrich SML3333 Dianhydrogalactitol ≥95% (HPLC) 23261-20-3 25MG $357 2024-03-01 Buy
TRC D720515 DulcitolDiepoxide 23261-20-3 10mg $150 2021-12-16 Buy
Usbiological 293253 1,2:5,6-Dianhydrogalactitol 23261-20-3 100mg $602 2021-12-16 Buy
ChemScene CS-1358 VAL-083 23261-20-3 10mg $300 2021-12-16 Buy
Product number Packaging Price Buy
SML3333 5MG $88.6 Buy
SML3333 25MG $357 Buy
D720515 10mg $150 Buy
293253 100mg $602 Buy
CS-1358 10mg $300 Buy

Dianhydrogalactitol Chemical Properties,Uses,Production

Uses

Dulcitol Diepoxide is a cytostatic drug. Dulcitol Diepoxide can be used for treatment of leukemia, lung cancer, multiple myeloma, and nasopharyngeal carcinoma.

Biological Activity

val-083 is a bi-functional alkylating agent, with potential antitumor activity.val-083 can cross the blood brain barrier and appears to be selective for tumor cells. val-083 alkylates and crosslinks dna which ultimately inhibit the proliferation of cancer cells. val-083 does not show cross-resistance to other conventional chemotherapeutic agents. the half-life of val-083 in the brain is long. val-083 has been assessed in multiple studies as chemotherapy in the treatment of newly diagnosed and recurrent brain tumors.

in vitro

VAL-083 is an alkylating agent that creates N7 methylation on DNA. VAL-083 suppresses U251 and SF188 cell growth and induces apoptosis after 72 h.

in vivo

VAL-083 (Dianhydrogalactitol; 25, 50, 100 μg/mL) dose-dependently inhibits angiogenesis in zebrafish model. VAL-083 considerably reduces VEGF, VEGFR2, and FGF2 expression at 25 μg/mL, and further causes reduction in FGFR2 expression at 50 μg/mL. It (1,2:5,6-dianhydrogalactitol; 5 mg/kg, iv, twice per week for 6 weeks) significantly blocks the growth of LN229 cells in mice with the relative tumor growth rate (T/C) of 22.38%, and the tumor growth inhibitory rate (TGI) of 83.58%. Moreover, VAL-083 dramatically activates the CDC25C-CDK1 cascade in the xenografted tumor moedl.

target

DNA

References

http://www. delmarpharma.com/product_development_programs/val083/

Dianhydrogalactitol Preparation Products And Raw materials

Raw materials

Preparation Products

Dianhydrogalactitol Suppliers

Global( 78)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30230 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22866 58
Alfa Chemistry 		Info@alfa-chemistry.com United States 24072 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501; +undefined18621343501 product@acmec-e.com China 33338 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58

View Lastest Price from Dianhydrogalactitol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
VAL-083 pictures 2025-04-29 VAL-083
23261-20-3
 US $48.00-148.00 / mg ≥98% 10g TargetMol Chemicals Inc.
Dianhydrodulcitol USP/EP/BP pictures 2021-07-06 Dianhydrodulcitol USP/EP/BP
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
  • VAL-083 pictures
  • VAL-083
    23261-20-3
  • US $48.00-148.00 / mg
  • ≥98%
  • TargetMol Chemicals Inc.

23261-20-3(Dianhydrogalactitol )Related Search:

Dianhydrogalactitol Dianhydrodulcitolum 1,2,5,6-DIANHYDRODULCITOL 1,2:5,6-Diepoxyhexane-3,4-diol 1,2-Di(oxiranyl)ethylene glycol Dulcitol diepoxide NSC-132313 1,2:5,6-Diepoxydulcitol 5,6-Diepoxydulcitol VAL 083 VAL083; VAL083; VAL083; DIANHYDRODULCITOL; DIANHYDROGALACTITOL; DULCITOL DIEPOXIDE; Galactitol, 1,2:5,6-dianhydro- Dianhydrodulcitol USP/EP/BP VAL-083 VAL083 1,2:5,6-Dianhydrogalactitol VAL-083，Dianhydrodulcitol VAL-083,Inhibitor,DNA Alkylator/Crosslinker,VAL 083,inhibit,VAL083 VAL-083, 10 mM in DMSO Dianhydrogalactitol (VAL-083) 23261-20-3 APIS