ChemicalBook >> CAS DataBase List >>LCI699
LCI699
- CAS No.
- 928134-65-0
- Chemical Name:
- LCI699
- Synonyms
- Osilodrostat;LCI699;CS-2488;LCI 699NX;Osilodrostat (LCI699);LCI-699 (Osilodrostat);Isturisa (Osilodrostat);Osilodrostat, 10 mM in DMSO;Osilodrostat(LCI699) free base;(R)-4-(6,7-Dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile
- CBNumber:
- CB32628027
- Molecular Formula:
- C13H10FN3
- Molecular Weight:
- 227.24
- MDL Number:
- MFCD25976825
- MOL File:
- 928134-65-0.mol
- MSDS File:
- SDS
Last updated:2025-04-17 18:22:24
| Boiling point | 433.8±45.0 °C(Predicted) |
|---|---|
| Density | 1.32±0.1 g/cm3(Predicted) |
| solubility |
DMSO:147.5(Max Conc. mg/mL);649.1(Max Conc. mM) Ethanol:72.5(Max Conc. mg/mL);319.05(Max Conc. mM) |
| form | A solid |
| pka | 6.97±0.40(Predicted) |
| color | White to yellow |
| FDA UNII | 5YL4IQ1078 |
| NCI Drug Dictionary | osilodrostat |
| ATC code | H02CA02 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
LCI699 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-6896 | Osilodrostat 99.17% | 928134-65-0 | 5mg | $100 | 2021-12-16 | Buy |
| ChemScene | CS-6896 | Osilodrostat 99.17% | 928134-65-0 | 10mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-6896 | Osilodrostat 99.17% | 928134-65-0 | 100mg | $850 | 2021-12-16 | Buy |
| Crysdot | CD11011508 | LCI699 95+% | 928134-65-0 | 50mg | $941 | 2021-12-16 | Buy |
| DC Chemicals | DC9974 | Isturisa(Osilodrostat) >98% | 928134-65-0 | 250mg | $1450 | 2021-12-16 | Buy |
LCI699 Chemical Properties,Uses,Production
Uses
Osilodrostat is a novel 11-β-hydroxylase inhibitor which may be used in the treatment of Cushing’s syndrome,
in vivo
Osilodrostat (LCI699; 0.1-100 mg/kg; p.o.; once) inhibits aldosterone and corticosterone synthesis in Ang-II- and ACTH-stimulated Sprague Dawley rats[1].
Osilodrostat (LCI699; 3-100 mg/kg; p.o.; daily, for 52 weeks) reduces mean arterial pressure and prolongs survival in dTG rats[1].
| Animal Model: | Male Ang-II- and ACTH-stimulated Sprague Dawley rats[1] |
| Dosage: | 0.1, 0.3, 1 and 3 mg/kg (Ang-II-stimulated rats) and 1, 3, 10, 30 and 100 mg/kg (ACTH-stimulated rats) |
| Administration: | Oral administration; once |
| Result: | Inhibited the increase in plasma aldosterone concentrations stimulated by Ang II or ACTH in a dose-dependent manner. |
| Animal Model: | dTG rats[1] |
| Dosage: | 3, 10, 30 and 100 mg/kg |
| Administration: | Oral administration; daily, for 52 weeks |
| Result: | Increased fractional LV (systolic and diastolic) shortening, normalized LV isovolumic relaxation time to RR (IVRT/RR) ratio and myocardial cell size and reduced LV weight in a dose-dependent manner. |
Synthesis of LCI699 from 1H-Imidazole-1-acetic acid, α-(4-cyano-2-fluorophenyl)-5-(2-hydroxyethyl)-, methyl ester
LCI699 Preparation Products And Raw materials
Raw materials
Preparation Products
LCI699 Suppliers
Global( 72)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20342 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38664 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
LCI699
4-(R)-(6,7-Dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile
4-[(5R)-6,7-Dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile
LCI 699NX
Osilodrostat (LCI699)
CS-2488
Osilodrostat(LCI699) free base
Benzonitrile, 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluoro-
Isturisa (Osilodrostat)
Osilodrostat
(R)-4-(6,7-Dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile
HAC15 cells,Cushing syndrome,primary human adrenocortical cell cultures,inhibit,LCI-699,Mineralocorticoid Receptor,CYP11B2,Osilodrostat,CYP11B1,LCI 699,Inhibitor,blood pressure
Osilodrostat, 10 mM in DMSO
LCI-699 (Osilodrostat)
928134-65-0