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ChemicalBook >> CAS DataBase List >>C6 Biotin Ceramide (d18:1/6:0)

C6 Biotin Ceramide (d18:1/6:0)

CAS No.
192070-02-3
Chemical Name:
C6 Biotin Ceramide (d18:1/6:0)
Synonyms
C6 Biotin Ceramide (d18:1/6:0);N-Hexanoyl-biotin-D-erythro-sphingosine;(3aS,4S,6aR)-hexahydro-N-[6-[[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]amino]-6-oxohexyl]-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide;1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-N-[6-[[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]amino]-6-oxohexyl]-2-oxo-, (3aS,4S,6aR)-
CBNumber:
CB24665612
Molecular Formula:
C34H62N4O5S
Molecular Weight:
638.94
MDL Number:
MFCD19705498
MOL File:
192070-02-3.mol
Last updated:2025-04-17 18:22:24

C6 Biotin Ceramide (d18:1/6:0) Properties

Boiling point 901.2±65.0 °C(Predicted)
Density 1.072±0.06 g/cm3(Predicted)
solubility DMF: Soluble
form A solid
pka 13.54±0.20(Predicted)

C6 Biotin Ceramide (d18:1/6:0) price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 9000415 C6 Biotin Ceramide (d18:1/6:0) ≥98% 192070-02-3 5mg $656 2024-03-01 Buy
Product number Packaging Price Buy
9000415 5mg $656 Buy

C6 Biotin Ceramide (d18:1/6:0) Chemical Properties,Uses,Production

Description

C6 Ceramide-biotin is an affinity probe that allows C2 ceramide (d18:1/2:0) to be detected or immobilized through interaction with the biotin ligand. C6 Ceramide-biotin has been used to detect ceramide binding partners, such as inhibitor 2 of protein phosphatase 2A (I2PP2A), in vitro and in situ.1 C6 ceramide is a cell-permeable analog of naturally occurring ceramides. With a longer carbon chain than C2 ceramide , it is somewhat more hydrophobic and may more closely mimic the effects of natural ceramides.2 C6 ceramide mediates many diverse biological activities including apoptosis, activation of PP2A, and inhibition of the mitochondrial respiratory chain.2,3,4,5 It also enhances the expression of COX-2 in rat granulosa cells and stimulates the growth of bovine aortic smooth muscle cells.6,7 C6 ceramide acts in neuronal axons to inhibit neurite growth.8

Uses

C6 Biotin ceramide (d18:1/6:0) is a biochemical reagent.

References

1. Mukhopadhyay, A., Saddoughi, S.A., Song, P., et al. Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling FASEB J. 23(3),751-763(2009).
2. Dobrowsky, R.T., and Hannun, Y.A. Ceramide stimulates a cytosolic protein phosphatase J. Biol. Chem. 267(8),5048-5051(1992).
3. Cai, Z., Bettaieb, A., El Mahdani, N., et al. Alteration of the sphingomyelin/ceramide pathway is associated with resistance of human breast carcinoma MCF7 cells to tumor necrosis factor-α-mediated cytotoxicity J. Biol. Chem. 272(11),6918-6926(1997).
4. Dobrowsky, R.T., Kamibayashi, C., Mumby, M.C., et al. Ceramide activates heterotrimeric protein phosphatase 2A J. Biol. Chem. 268(21),15523-15530(1993).
5. Gudz, T.I., Tserng, K.Y., and Hoppel, C.L. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide J. Biol. Chem. 272(39),24154-24158(1997).
6. Santana, P., Llanes, L., Hernandez, I., et al. Interleukin-1β stimulates sphingomyelin hydrolysis in cultured granulosa cells: Evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis Endocrinology 137(6),2480-2489(1996).
7. Augé, N., Andrieu, N., Nègre-Salvayre, A., et al. The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation J. Biol. Chem. 271(32),19251-19255(1996).
8. Posse de Chaves, E.I., Bussière, M., Vance, D.E., et al. Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons J. Biol. Chem. 272(4),2038-3035(1997).

C6 Biotin Ceramide (d18:1/6:0) Preparation Products And Raw materials

Raw materials

Preparation Products

C6 Biotin Ceramide (d18:1/6:0) Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8140 58
ChemeGen 中國 18818260767 2625930290@qq.com China 6973 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 21356 58
SHANGHAI ZZBIO CO., LTD. 15102117276 19921389125 tech@zzbioco.com China 12064 58
4008-099-669 23419001name@qq.com CHINA 6043 58
Cayman Chemical Company 800-364-9897 sales@caymanchem.com China 6838 58
Enzo Biochem Inc Enzo Biochem Inc. 13797054060 Enzoname@qq.com China 6174 58
C6 Biotin Ceramide (d18:1/6:0) N-Hexanoyl-biotin-D-erythro-sphingosine 1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-N-[6-[[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]amino]-6-oxohexyl]-2-oxo-, (3aS,4S,6aR)- (3aS,4S,6aR)-hexahydro-N-[6-[[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]amino]-6-oxohexyl]-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide 192070-02-3