5-Hydroxy-2-methylindole
- CAS No.
- 13314-85-7
- Chemical Name:
- 5-Hydroxy-2-methylindole
- Synonyms
- 5-Hydroxy-2-methyL;2-Methyl-5-Indanone;2-METHYL-1H-INDOL-5-OL;5-Hydroxy-2-methylindol;1H-Indol-5-ol,2-Methyl-;5-HYDROXY-2-METHYLINDOLE;5-Hydroxy-2-methylindole,98%;5-Hydroxy-2-Methyl-1H-indole
- CBNumber:
- CB2351265
- Molecular Formula:
- C9H9NO
- Molecular Weight:
- 147.17
- MDL Number:
- MFCD00022714
- MOL File:
- 13314-85-7.mol
- MSDS File:
- SDS
| Melting point | 130-132℃ |
|---|---|
| Boiling point | 344.8±22.0 °C(Predicted) |
| Density | 1.262±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| form | Solid |
| pka | 10.05±0.40(Predicted) |
| color | Brown |
| Sensitive | Light Sensitive |
| CAS DataBase Reference | 13314-85-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
5-Hydroxy-2-methylindole price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M321593 | 2-Methyl-1H-indol-5-ol | 13314-85-7 | 10mg | $45 | 2021-12-16 | Buy |
| Matrix Scientific | 138117 | 2-Methyl-1H-indol-5-ol 95%+ | 13314-85-7 | 2.500g | $215 | 2021-12-16 | Buy |
| AK Scientific | Z4093 | 2-Methyl-1H-indol-5-ol | 13314-85-7 | 10g | $270 | 2021-12-16 | Buy |
| Matrix Scientific | 138117 | 2-Methyl-1H-indol-5-ol 95%+ | 13314-85-7 | 5g | $323 | 2021-12-16 | Buy |
| Matrix Scientific | 138117 | 2-Methyl-1H-indol-5-ol 95%+ | 13314-85-7 | 1g | $101 | 2021-12-16 | Buy |
5-Hydroxy-2-methylindole Chemical Properties,Uses,Production
Application
5-Hydroxy-2-methylindole is a useful research chemical.
Synthesis
1076-74-0
13314-85-7
The general procedure for the synthesis of 5-hydroxy-2-methylindole from 5-methoxy-2-methylindole was as follows: a solution of boron tribromide (32.5 mL, 341 mmol) in dichloromethane (60 mL) was added batchwise to a solution of 5-methoxy-2-methylindole (25 g, 155 mmol) in dichloromethane (250 mL) that had been cooled to -50 °C. After stirring the reaction mixture at -30 °C for 15 min, it was slowly warmed to room temperature and stirring was continued for 1 hour. Subsequently, dichloromethane (300 mL) was added in batches and the reaction mixture was cooled to 0 °C. Water was slowly added and the pH of the mixture was adjusted to 6 with 4N sodium hydroxide solution. the organic layer was separated and the aqueous layer was extracted with dichloromethane. All organic layers were combined, washed sequentially with water and saturated brine and dried over anhydrous magnesium sulfate. The solvent was removed by evaporation under reduced pressure and the resulting crude product was purified by column chromatography with the eluent ethyl acetate/dichloromethane (initial ratio 1:9, subsequently adjusted to 15:85) to give 5-hydroxy-2-methylindole (21.2 g, 93% yield) as a white solid.
References
[1] European Journal of Medicinal Chemistry, 2013, vol. 63, p. 578 - 588
[2] Patent: US2003/212055, 2003, A1
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 5, p. 1940 - 1956
[4] Research on Chemical Intermediates, 2010, vol. 36, # 8, p. 975 - 983
[5] Bioorganic and medicinal chemistry, 2004, vol. 12, # 17, p. 4685 - 4700
5-Hydroxy-2-methylindole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86-13288715578 | sales@hbmojin.com | China | 12647 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | alfa10@alfachem.cn | China | 13006 | 58 |
View Lastest Price from 5-Hydroxy-2-methylindole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-07 | 5-Hydroxy-2-methylindole
13314-85-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-06-24 | 5-Hydroxy-2-methylindole
13314-85-7
|
US $9.85 / KG | 1KG | 99% | 10 m | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-04-04 | 5-Hydroxy-2-methylindole
13314-85-7
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 5-Hydroxy-2-methylindole
13314-85-7
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 5-Hydroxy-2-methylindole
13314-85-7
- US $9.85 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 5-Hydroxy-2-methylindole
13314-85-7
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
