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ChemicalBook >> CAS DataBase List >>Axitinib Impurity a

Axitinib Impurity a

CAS No.
1347304-18-0
Chemical Name:
Axitinib Impurity a
Synonyms
Axitinib C;PF03482595);Axitinib M12;Axitinib Sulfoxide;Axitinib Impurity a;Axitinib metabolite M12;Axitinib sulfoxide (AG028458;N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfinyl]benzamide;N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]benzamide;Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-
CBNumber:
CB23038983
Molecular Formula:
C22H18N4O2S
Molecular Weight:
402.47
MDL Number:
MFCD30747237
MOL File:
1347304-18-0.mol
Last updated:2023-05-18 11:31:17

Axitinib Impurity a Properties

Melting point >225 (dec.)
Boiling point 720.6±60.0 °C(Predicted)
Density 1.43±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly, Heated)
form Solid
pka 11.70±0.40(Predicted)
color Light Yellow
FDA UNII 55P8GY3IEK

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H361
Precautionary statements  P264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501

Axitinib Impurity a price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 28042 Axitinib Sulfoxide 1347304-18-0 1mg $62 2024-03-01 Buy
Cayman Chemical 28042 Axitinib Sulfoxide 1347304-18-0 5mg $211 2024-03-01 Buy
TRC A794885 AxitinibSulfoxide 1347304-18-0 10mg $345 2021-12-16 Buy
AK Scientific 5029EA Axitinibsulfoxide 1347304-18-0 1mg $166 2021-12-16 Buy
Product number Packaging Price Buy
28042 1mg $62 Buy
28042 5mg $211 Buy
A794885 10mg $345 Buy
5029EA 1mg $166 Buy

Axitinib Impurity a Chemical Properties,Uses,Production

Description

Axitinib sulfoxide is a major inactive metabolite of the tyrosine kinase inhibitor axitinib . It is formed from axitinib primarily by the cytochrome P450 (CYP) isoform CYP3A4 with minor contributions from CYP3A5 and CYP2C19.

Uses

Axitinib Sulfoxide is a major metabolite of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

Axitinib Impurity a Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 66)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
CR Corporation Limited 		+8613062833949 fred.wen@crcorporation.cn China 8647 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
China National Standard Pharmaceutical Corporation Limited 		+8615391658522 overseasales@yongstandards.com China 11922 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 10986 58
Guangzhou CATO Research Chemicals Inc. 		+86-020-81960175-617 +8615602392859 Intermediate@cato-chem.com China 6335 58
Moxin Chemicals 		+8617320513646 mike@molcoo.com China 9720 58
Pure Research Chemicals 		13564847951 18019592524 info@purerechem.com China 946 58
Axitinib Impurity a Axitinib Sulfoxide Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]- Axitinib C Axitinib sulfoxide (AG028458 PF03482595) Axitinib M12 N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]benzamide N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfinyl]benzamide Axitinib Impurity 5/Axitinib Sulfoxide/N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide Axitinib metabolite M12 (E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)sulfinyl)benzamide (Axitinib Impurity) 1347304-18-0