3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone
![3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone Structure](CAS/20150408/GIF/1402830-75-4.gif)
- CAS No.
- 1402830-75-4
- Chemical Name:
- 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone
- Synonyms
- Ceranib-2 >=98% (HPLC);Ceranib-2, 10 mM in DMSO;3-[3-(4-Methoxyphenyl)-1-oxo-2-propenyl]-4-phenyl-2(1H)-quinolinone;3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone;2(1H)-Quinolinone, 3-[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-;3-[(2E)-3-(4-Methoxyphenyl)prop-2-enoyl]-4-phenyl-1,2-dihydroquinolin-2-one
- CBNumber:
- CB22715575
- Molecular Formula:
- C25H19NO3
- Molecular Weight:
- 381.42326
- MDL Number:
- MFCD25977826
- MOL File:
- 1402830-75-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H413 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0607 | Ceranib-2 ≥98% (HPLC) | 1402830-75-4 | 5mg | $93.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0607 | Ceranib-2 ≥98% (HPLC) | 1402830-75-4 | 25mg | $361 | 2024-03-01 | Buy |
| Cayman Chemical | 11092 | Ceranib-2 ≥98% | 1402830-75-4 | 5mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 11092 | Ceranib-2 ≥98% | 1402830-75-4 | 10mg | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 11092 | Ceranib-2 ≥98% | 1402830-75-4 | 25mg | $270 | 2024-03-01 | Buy |
3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone Chemical Properties,Uses,Production
Description
Ceranib-2 is a ceramidase inhibitor that inhibits ceramidase activity (IC50 = 28 μM in SKOV3 cells). It also increases intracellular accumulation of various ceramides, including C14 ceramide , C24 ceramide , C26 ceramide, and C26:1 ceramide, and total ceramide levels and decreases levels of dihydrosphingosine, sphingosine, and sphingosine-1-phosphate in SKOV3 cells. In vivo, ceranib-2 (20 and 50 mg/kg, i.p.) reduces tumor volume in a JC mammary adenocarcinoma mouse syngeneic tumor model.
Uses
Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and induces cell apoptosis. Anticancer activity[1][2].
in vivo
Ceranib-2 (20-50 mg/kg; intraperitoneal injection; daily for 5 days per week; for 3 weeks; female Balb/c mice) treatment delays tumor growth in a syngeneic tumor model without hematologic suppression or overt signs of toxicity[1].
Intraperitoneal administration of 50 mg/kg Ceranib-2 results in progressive increases in its circulating levels, reaching a peak plasma concentration of approximately 40 μM at the 2 hr time point. Ceranib-2 appears to be cleared with a half-life of less than 2 hr[1].
| Animal Model: | Female Balb/c mice injected with JC murine mammary adenocarcinoma cells[1] |
| Dosage: | 20 mg/kg or 50 mg/kg |
| Administration: | Intraperitoneal injection; daily for 5 days per week; for 3 weeks |
| Result: | Delayed tumor growth in a syngeneic tumor model. |
References
[1] Draper JM, et al. Discovery and evaluation of inhibitors of human ceramidase. Mol Cancer Ther. 2011 Nov;10(11):2052-61. DOI:10.1158/1535-7163.MCT-11-0365
[2] Kus G, et al. Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2. In Vitro Cell Dev Biol Anim. 2015 Nov;51(10):1056-63. DOI:10.1007/s11626-015-9932-9
3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone Preparation Products And Raw materials
Raw materials
Preparation Products
3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| DKMbiochem.Co. Ltd | 15901859516 | sales@DKMbiochem.com | China | 344 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
