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ChemicalBook >> CAS DataBase List >>PBTZ169

PBTZ169

CAS No.
1377239-83-2
Chemical Name:
PBTZ169
Synonyms
CS-2309;Macozinone;PBTZ169 (PBTZ 169;Macozinone(PBTZ169);Macozinone, 10 mM in DMSO;PBTZ169;PBTZ-169;PBTZ 169;2-(4-(Cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-trifluoromethyl-4H-1,3-benzothiazin-4-one; 2-[4-(Cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one;4H-1,3-Benzothiazin-4-one, 2-[4-(cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-;2-(4-(Cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one
CBNumber:
CB03128778
Molecular Formula:
C20H23F3N4O3S
Molecular Weight:
456.48
MDL Number:
MOL File:
1377239-83-2.mol
Last updated:2024-07-02 08:54:57

PBTZ169 Properties

storage temp. Store at -20°C
solubility DMSO:4.6(Max Conc. mg/mL);10.1(Max Conc. mM)
form A crystalline solid
color Light yellow to yellow
FDA UNII A3M1353L40

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
NFPA 704
0
2 0

PBTZ169 price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22202 PBTZ169 ≥98% 1377239-83-2 1mg $32 2024-03-01 Buy
Cayman Chemical 22202 PBTZ169 ≥98% 1377239-83-2 5mg $139 2024-03-01 Buy
Cayman Chemical 22202 PBTZ169 ≥98% 1377239-83-2 10mg $243 2024-03-01 Buy
Cayman Chemical 22202 PBTZ169 ≥98% 1377239-83-2 25mg $533 2024-03-01 Buy
TRC P216563 PBTZ169 1377239-83-2 5mg $140 2021-12-16 Buy
Product number Packaging Price Buy
22202 1mg $32 Buy
22202 5mg $139 Buy
22202 10mg $243 Buy
22202 25mg $533 Buy
P216563 5mg $140 Buy

PBTZ169 Chemical Properties,Uses,Production

Description

PBTZ169 is an antibiotic with antimycobacterial activity. It is an irreversible inhibitor of DprE1, an essential enzyme for cell wall synthesis in mycobacteria. PBTZ169 is active against M. tuberculosis in vitro (MIC = ≤0.19 ng/ml) without inducing cytotoxicity in Vero cells when used at concentrations up to 125 μM. It reduces the bacterial burden in the lung and spleen in a mouse model of chronic tuberculosis when administered at a dose of 50 mg/kg per day.

Uses

PBTZ169 is a potent irreversible inhibitor of decaprenylphosphoryl-beta-D-ribose 2-epimerase (DprE1), and display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.

PBTZ169 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 65)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29807 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38664 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55

View Lastest Price from PBTZ169 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-[4-(Cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one pictures 2020-01-02 2-[4-(Cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one
1377239-83-2
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
2-(4-(Cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-trifluoromethyl-4H-1,3-benzothiazin-4-one Macozinone PBTZ169;PBTZ-169;PBTZ 169 CS-2309 PBTZ169 (PBTZ 169 2-[4-(Cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one 4H-1,3-Benzothiazin-4-one, 2-[4-(cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)- 2-(4-(Cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one Macozinone(PBTZ169) Macozinone, 10 mM in DMSO 1377239-83-2