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ChemicalBook >> CAS DataBase List >>AVL-292

AVL-292

CAS No.
1202757-89-8
Chemical Name:
AVL-292
Synonyms
CC-292;CS-733;LMK-435;AVL-292;Spebrutinib;AVL-292 >=98%;CC-292,LMK-435;CC-292 (AVL-292);AVL 292 - CC 292;AVL-292 USP/EP/BP
CBNumber:
CB02655392
Molecular Formula:
C22H22FN5O3
Molecular Weight:
423.44
MDL Number:
MFCD25976876
MOL File:
1202757-89-8.mol
Last updated:2024-07-02 08:54:57

AVL-292 Properties

Density 1.322±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≥21.15 mg/mL in DMSO; insoluble in H2O; ≥4.9 mg/mL in EtOH with gentle warming and ultrasonic
form solid
pka 13.22±0.70(Predicted)
color White to khaki
CAS DataBase Reference 1202757-89-8
FDA UNII DRU6NG543J

AVL-292 price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17993 AVL-292 ≥98% 1202757-89-8 1mg $44 2024-03-01 Buy
Cayman Chemical 17993 AVL-292 ≥98% 1202757-89-8 5mg $193 2024-03-01 Buy
Cayman Chemical 17993 AVL-292 ≥98% 1202757-89-8 10mg $341 2024-03-01 Buy
Cayman Chemical 17993 AVL-292 ≥98% 1202757-89-8 50mg $957 2024-03-01 Buy
TRC A794715 AVL-292 1202757-89-8 100mg $610 2021-12-16 Buy
Product number Packaging Price Buy
17993 1mg $44 Buy
17993 5mg $193 Buy
17993 10mg $341 Buy
17993 50mg $957 Buy
A794715 100mg $610 Buy

AVL-292 Chemical Properties,Uses,Production

Uses

Bruton’s tyrosine kinase (BTK) is a non-receptor tyrosine kinase involved in signal transduction pathways regulating the proliferation, activation, and differentiation of B cells. AVL-292 is an orally available, selective, and irreversible inhibitor of BTK (IC50 = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481, thereby preventing its activity. AVL-292 has been shown to inhibit osteoclast function and to reduce osteoclast-stimulated proliferation of multiple myeloma cells in animal models of rheumatoid arthritis and multiple sclerosis, both of which are diseases where B cells play an important role. In clinical trials, AVL-292 has demonstrated therapeutic significance in the treatment of both B cell-related cancers (e.g., non-Hodgkin’s lymphoma and B cell chronic lymphocytic leukemia) and autoimmune diseases (e.g., rheumatoid arthritis).[Cayman Chemical]

target

Btk

AVL-292 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 164)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29856 58
Zhejiang ZETian Fine Chemicals Co. LTD 		+8618957127338 stella@zetchem.com China 2136 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22866 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58

View Lastest Price from AVL-292 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AVL-292 pictures 2022-02-18 AVL-292
1202757-89-8
 US $0.00 / gram 1gram 99% 10kg Zhejiang J&C Biological Technology Co.,Limited
AVL-292 pictures 2019-07-06 AVL-292
1202757-89-8
 US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co
  • AVL-292 pictures
  • AVL-292
    1202757-89-8
  • US $0.00 / gram
  • 99%
  • Zhejiang J&C Biological Technology Co.,Limited
  • AVL-292 pictures
  • AVL-292
    1202757-89-8
  • US $2.00 / kg
  • 99%
  • Career Henan Chemical Co

AVL-292 Spectrum

1202757-89-8(AVL-292)Related Search:

AVL-292 LMK-435 N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide 2-Propenamide, N-[3-[[5-fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]- CC-292 (AVL-292) CC-292,LMK-435 N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide AVL292 CC-292 Spebrutinib AVL-292 (Spebrutinib) AVL-292 >=98% N-(3-((5-fluoro-2-((4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide N-(3-((5-fluoroethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide CS-733 N-(3-((5-fluoroethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide (AVL-292) CC-292; AVL292; AVL-292; AVL 292 AVL 292 - CC 292 CC-292;AVL292;AVL-292;AVL 292;SPEBRUTINIB Spebrutinib (AVL-292) Spebrutinib (CC-292, AVL-292) N-{3-[(5-Fluoro-2-{[4-(2-methoxyethoxy)phenyl]amino}pyrimidin-4-yl)amino]phenyl}prop-2-enamide AVL-292 USP/EP/BP Spebrutinib (CC292 7-Epoxytropine hydrochloride Spebrutinib, 10 mM in DMSO 1202757-89-8 Inhibitors