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ChemicalBook >> CAS DataBase List >>(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID

(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID

CAS No.
844639-57-2
Chemical Name:
(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID
Synonyms
TM30089;CS-1157;TM30089 Racemate;CAY10471 Racemate;TM 30089;TM-30089;TM30089 (CAY10471);CAY10471 Racemate, 10 mM in DMSO;9H-Carbazole-9-acetic acid, 3-[[(4-fluorophenyl)sulfonyl]MethylaMino]-1,2,3,4-tetrahydro-;(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID;CAY 10471,CAY10471,TM30089,Inhibitor,CAY-10471,TM 30089,TM-30089,CAY10471 Racemate,inhibit,Prostaglandin Receptor,CAY-10471 Racemate
CBNumber:
CB02448675
Molecular Formula:
C21H21FN2O4S
Molecular Weight:
416.47
MDL Number:
MFCD08062186
MOL File:
844639-57-2.mol
Last updated:2025-04-28 21:36:36

(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID Properties

Melting point 165-173℃ (dichloromethane )
Boiling point 639.1±65.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 150 mg/mL (360.17 mM)
form Solid
pka 4.33±0.10(Predicted)
color Off-white to light yellow
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H315-H317-H319-H410
Precautionary statements  P273-P280-P302+P352-P305+P351+P338

(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2743 TM30089 ≥98% (HPLC) 844639-57-2 5MG $124 2024-03-01 Buy
Sigma-Aldrich SML2743 TM30089 ≥98% (HPLC) 844639-57-2 25MG $495 2024-03-01 Buy
Biorbyt Ltd orb181174 TM30089 >98% 844639-57-2 100mg $578 2021-12-16 Buy
American Custom Chemicals Corporation BIO0000169 TM-30089 95.00% 844639-57-2 10MG $727.65 2021-12-16 Buy
ChemScene CS-0007735 CAY10471Racemate 99.35% 844639-57-2 10mg $140 2021-12-16 Buy
Product number Packaging Price Buy
SML2743 5MG $124 Buy
SML2743 25MG $495 Buy
orb181174 100mg $578 Buy
BIO0000169 10MG $727.65 Buy
CS-0007735 10mg $140 Buy

(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID Chemical Properties,Uses,Production

Uses

CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective prostaglandin D2 receptor CRTH2 antagonist, with a Ki of 0.6 nM for hCRTH2, selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM). CAY10471 Racemate also has effect on mouse and rat orthologs of CRTH2[1].

Biological Activity

TM30089 is a ramatroban analog and an orally active, high-affinity, potent and selective prostaglandin D2 receptor 2 (DP2; CRTH2) antagonist (Ki = 0.6 nM/hDP2 against 1.2 nM PGD2; Ki = 1.2 μM/hDP1 against 0.5 nM PGD2, >10 μM/hTP against 5 nM SQ29548) th at blocks PGD2-induced responses in hDP2 transfectants (IP1/βarr IC50 = 1.2/3.0 nM) and exhibits in vivo efficacy in a murine model of renal tubulointerstitial fibrosis (20 mg/kg b.i.d. p.o., starting 4 days before or 3 days after unilateral ureteral obstruction/UUO).

IC 50

CRTH2: 0.6 nM (Ki)

References

[1] Ulven T, et al. Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. J Med Chem. 2005 Feb 24;48(4):897-900. DOI:10.1021/jm049036i

(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 37)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15411 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38664 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9891 58
Shanghai Synchem Pharma Co., ltd 21-619849051-1 18521059765 synchempharma@aliyun.com China 6466 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 17801761073 3193328036@qq.com China 29763 68

View Lastest Price from (+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CAY10471 Racemate pictures 2025-04-27 CAY10471 Racemate
844639-57-2
 US $43.00-143.00 / mg ≥98% 10g TargetMol Chemicals Inc.

844639-57-2((+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID)Related Search:

TM30089 9H-Carbazole-9-acetic acid, 3-[[(4-fluorophenyl)sulfonyl]MethylaMino]-1,2,3,4-tetrahydro- CS-1157 TM30089 (CAY10471) TM 30089;TM-30089 CAY10471 Racemate TM30089 Racemate (+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID CAY 10471,CAY10471,TM30089,Inhibitor,CAY-10471,TM 30089,TM-30089,CAY10471 Racemate,inhibit,Prostaglandin Receptor,CAY-10471 Racemate CAY10471 Racemate, 10 mM in DMSO 844639-57-2