1,4-二氫-2,6-二甲基-5-硝基-4-(2-[三氟甲基]苯基)吡啶-3-羧酸甲酯
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- CAS號:
- 71145-03-4
- 英文名:
- (+/-)-BAY K 8644
- 英文別名:
- SQ-28873;(±)-BAY-K-8644;(RS)-BAY K 8644;BAY K-8644 (+/-);(+/-)-BAY K 8644;(±)-Bay K 8644,98%;BAYK 8644 (racemate);BAYK 8644; BAYK8644; BAYK-8644;(+/-)-BAY K8644 CALCIUM SLOW CHANNEL;(+/-)-Bay K8644 calcium channel agonist
- 中文名:
- 1,4-二氫-2,6-二甲基-5-硝基-4-(2-[三氟甲基]苯基)吡啶-3-羧酸甲酯
- 中文別名:
- 氟硝尼啶;API,氟硝尼啶;BAY K 8644游離;化合物BAY K 8644;(±)-BAYK8644,L型CA 2+通道激活劑;(±)-BAYK8644,L-TYPE CA2+ CHANNEL活化劑;(±)-BAYK8644,L-TYPE CA2+ CHANNEL活化劑;2,6-二甲基-5-硝基-4-(2-(三氟甲基)苯基)-1,4-二氫吡啶-3-羧酸甲酯;1,4-二氫-2,6-二甲基-5-硝基-4-(2-[三氟甲基]苯基)吡啶-3-羧酸甲酯
- CBNumber:
- CB9471784
- 分子式:
- C16H15F3N2O4
- 分子量:
- 356.3
- MOL File:
- 71145-03-4.mol
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1,4-二氫-2,6-二甲基-5-硝基-4-(2-[三氟甲基]苯基)吡啶-3-羧酸甲酯化學(xué)性質(zhì)
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熔點:
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166 °C
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沸點:
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429.2±45.0 °C(Predicted)
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密度:
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1.3548 (estimate)
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RTECS號:
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US5655000
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儲存條件:
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2-8°C
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溶解度:
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DMSO: 184 mg/mL
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酸度系數(shù)(pKa):
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-3.43±0.70(Predicted)
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形態(tài):
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Yellow solid.
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顏色:
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Yellow
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水溶解性:
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Soluble in DMSO at 20mg/ml. Also soluble in methanol or ethanol at 60mg/ml. Insoluble in water
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穩(wěn)定性:
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Stable. Incompatible with strong oxidizing agents.
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1,4-二氫-2,6-二甲基-5-硝基-4-(2-[三氟甲基]苯基)吡啶-3-羧酸甲酯性質(zhì)、用途與生產(chǎn)工藝
BAY K8644 是一種L 型Ca
2+通道激活劑，具有正性肌力作用和血管收縮作用，可用作活性 L 型鈣通道激動劑。
Bay K 8644是一種高選擇性的L型鈣離子通道激動劑，EC50為17.3 nM。
| Target | Value |
L-type calcium channel
(in the isolated field-stimulated vas deferens of the mouse)
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17.3nM(EC50)
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Bay K 8644 作為L型鈣離子的激動劑，提高了取自大鼠的腸系膜動脈的靜息張力。
Bay K 8644 可誘導(dǎo)5周齡、3月齡、1年、1.5年齡wistar-kyoto大鼠主動脈的小的收縮，這一現(xiàn)象不受大鼠年齡所影響。
1,4-二氫-2,6-二甲基-5-硝基-4-(2-[三氟甲基]苯基)吡啶-3-羧酸甲酯
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2025/02/08 | HY-10588 | 1,4-二氫-2,6-二甲基-5-硝基-4-(2-[三氟甲基]苯基)吡啶-3-羧酸甲酯
Bay K 8644 | 71145-03-4 | 1 mg | 454元 |
| 2025/02/08 | HY-10588 | 1,4-二氫-2,6-二甲基-5-硝基-4-(2-[三氟甲基]苯基)吡啶-3-羧酸甲酯
Bay K 8644 | 71145-03-4 | 5mg | 1000元 |
1,4-二氫-2,6-二甲基-5-硝基-4-(2-[三氟甲基]苯基)吡啶-3-羧酸甲酯
生產(chǎn)廠家
71145-03-4, 1,4-二氫-2,6-二甲基-5-硝基-4-(2-[三氟甲基]苯基)吡啶-3-羧酸甲酯 相關(guān)搜索:
- Calcium channel
- 合成有機(jī)化合物配體
- 抑制劑
- Biochemicals and Reagents
- BioChemical
- Enzyme Inhibitors
- Enzyme Inhibitors by Type
- Enzymes, Inhibitors, and Substrates
- Substrate Analogs
- (±)-BAYK8644,L-TYPE CA2+ CHANNEL活化劑
- (±)-BAYK8644,L-TYPE CA2+ CHANNEL活化劑
- (±)-BAYK8644,L型CA 2+通道激活劑
- 化合物BAY K 8644
- BAY K 8644游離
- 2,6-二甲基-5-硝基-4-(2-(三氟甲基)苯基)-1,4-二氫吡啶-3-羧酸甲酯
- API,氟硝尼啶
- 氟硝尼啶
- 1,4-二氫-2,6-二甲基-5-硝基-4-(2-[三氟甲基]苯基)吡啶-3-羧酸甲酯
- 71145-03-4
- (±)-BAY-K-8644
- (±)-BAYK8644, L-type Ca2+ channel activator
- (±)-BAYK8644, L-type Ca2+ channel activator
- Methyl (R)-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylate
- Bay K8644,influx,L-type,inhibit,sarcolemmal,Ca2+ channels,(±)-Bay K 8644,Bay K-8644,Bay K 8644,Inhibitor,Ca channels,Ca2+,Calcium Channel
- Methyl 2,6-dimethyl-3-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-5-carboxylate
- Methyl 2,6-dimethyl-3-nitro-4-[2-(trifluoromethyl)phenyl]-1,...
- BAYK 8644 (racemate)
- (+/-)-Bay K8644 calcium channel agonist
- BAYK 8644; BAYK8644; BAYK-8644
- (4R)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylic acid methyl ester
- methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
- (±)-Bay K 8644,98%
- SQ-28873
- (RS)-BAY K 8644
- 1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester
- (+/-)-BAY K8644 CALCIUM SLOW CHANNEL
- 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-diMethyl-5-nitro-4-[2-(trifluoroMethyl)phenyl]-, Methyl ester
- BAY K-8644 (+/-)
- (+/-)-BAY K 8644
- 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-[TRIFLUOROMETHYL]PHENYL)PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER
- 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[2-(TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID, METHYL ESTER
- 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[2'-(TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER