CUDA
|
|
|
- CAS號:
- 479413-68-8
- 英文名:
- CUDA
- 英文別名:
- CUDA;CUDA Exclusive;CUDA, 10 mM in DMSO;HPTJABJPZMULFH-UHFFFAOYSA-N;Dodecanoic acid, 12-[[(cyclohexylamino)carbonyl]amino]-;PPARalpha,epoxide,Peroxisome proliferator-activated receptors,cardiovascular,Inhibitor,peroxisome,Soluble,inhibit,disease,receptor,sEH,proliferator-activated,PPAR,Epoxide Hydrolase,hypotensive,CUDA,PPARα,hydrolase,lipid-lowering
- 中文名:
- CUDA
- 中文別名:
- 卡達;化合物CUDA;12-(3-環(huán)己基脲基)十二烷酸;化合物CUDA,10 MM DMSO 溶液
- CBNumber:
- CB82590750
- 分子式:
- C19H36N2O3
- 分子量:
- 340.5
- MOL File:
- 479413-68-8.mol
|
|
|
CUDA化學(xué)性質(zhì)
-
沸點:
-
549.4±19.0 °C(Predicted)
-
|
-
密度:
-
1.03±0.1 g/cm3(Predicted)
-
|
-
儲存條件:
-
Store at -20°C
-
|
-
溶解度:
-
≤1mg/ml in ethanol;5mg/ml in DMSO;10mg/ml in dimethyl formamide
-
|
-
形態(tài):
-
crystalline solid
-
|
-
酸度系數(shù)(pKa):
-
4.78±0.10(Predicted)
-
|
-
顏色:
-
White to off-white
-
|
CUDA性質(zhì)、用途與生產(chǎn)工藝
CUDA 是一種有效的可溶性環(huán)氧水解酶 (sEH) 抑制劑，對小鼠 sEH 和人 sEH 作用的 IC50 分別為 11.1 nM 和 112 nM。CUDA 能選擇性地上調(diào)過氧化物酶體增殖激活受體 PPARalpha 的活性。CUDA 可能對心血管疾病的研究有價值。
|
PPARα
|
mouse sEH
11.1 nM (IC
50
)
|
human sEH
112 nM (IC
50
)
|
CUDA (10 μM; 18 hours) produces 6- and 3-fold increases of PPARalpha in COS-7 cells.
CUDA does not alter PPARalpha protein expression, and it competitively inhibits the binding of Wy-14643 (pirinixic acid) to the ligand binding domain of PPARalpha, suggesting that it functions as a PPARalpha ligand.
Western Blot Analysis
|
Cell Line:
|
COS-7 cells
|
|
Concentration:
|
10 μM
|
|
Incubation Time:
|
18 hours
|
|
Result:
|
Activated PPARα by binding to the ligand binding domain of PPARα.
|
CUDA
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2025/02/08 | HY-121538 | CUDA
CUDA | 479413-68-8 | 5mg | 500元 |
| 2025/02/08 | HY-121538 | CUDA
CUDA | 479413-68-8 | 10 mM * 1 mLin DMSO | 550元 |
479413-68-8, CUDA 相關(guān)搜索:
- 抑制劑
- 小分子
- 抗體-二抗
- 化合物CUDA,10 MM DMSO 溶液
- 12-(3-環(huán)己基脲基)十二烷酸
- 卡達
- 化合物CUDA
- 479413-68-8
- CUDA, 10 mM in DMSO
- PPARalpha,epoxide,Peroxisome proliferator-activated receptors,cardiovascular,Inhibitor,peroxisome,Soluble,inhibit,disease,receptor,sEH,proliferator-activated,PPAR,Epoxide Hydrolase,hypotensive,CUDA,PPARα,hydrolase,lipid-lowering
- Dodecanoic acid, 12-[[(cyclohexylamino)carbonyl]amino]-
- HPTJABJPZMULFH-UHFFFAOYSA-N
- CUDA Exclusive
- CUDA