ACBI1
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- CAS號:
- 2375564-55-7
- 英文名:
- ACBI1
- 英文別名:
- ACBI1;PROTACs,anti-proliferative,ACBI 1,Epigenetic Reader Domain,ACBI1,Inhibitor,Apoptosis,inhibit,ACBI-1;N-[(1-Fluorocyclopropyl)carbonyl]-3-methyl-L-valyl-(4R)-N-[2-{2-[4-({4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinyl}methyl)phenoxy]ethoxy}-4-(4-methyl-1,3-thiazol-5-yl)benzyl]-4-hydroxy-L-prolinamide;(2S,4R)-N-(2-(2-(4-((4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide
- 中文名:
- ACBI1
- 中文別名:
- 化合物ACBI1;ACBI1 試劑;ACBI1 試劑;(2S,4R)-N-(2-(2-(4-((4-(3-氨基-6-(2-羥基苯基)噠嗪-4-基)哌嗪-1-基)甲基)苯氧基)乙氧基)-4-(4-甲基噻唑-5-基)芐基)-1-((S)-2-(1-氟環(huán)丙烷-1-甲酰胺基)-3,3-二甲基丁?；?-4-羥基吡咯烷-2-甲酰胺
- CBNumber:
- CB75848938
- 分子式:
- C49H58FN9O7S
- 分子量:
- 936.12
- MOL File:
- 2375564-55-7.mol
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ACBI1化學(xué)性質(zhì)
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沸點:
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1144.1±65.0 °C(Predicted)
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密度:
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1.41±0.1 g/cm3(Predicted)
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酸度系數(shù)(pKa):
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6.22±0.30(Predicted)
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形態(tài):
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Solid
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顏色:
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White to yellow
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InChIKey:
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IVARZBJJMMUJHI-SSIILETPNA-N
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SMILES:
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NC1N=NC(C2C=CC=CC=2O)=CC=1N1CCN(CC2C=CC(OCCOC3C=C(C4SC=NC=4C)C=CC=3CNC([C@@H]3C[C@@H](O)CN3C(=O)[C@H](C(C)(C)C)NC(C3(CC3)F)=O)=O)=CC=2)CC1 |&1:42,44,50,r|
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ACBI1性質(zhì)、用途與生產(chǎn)工藝
ACBI1 是一種有效的，基于 PROTAC 技術(shù)的 BAF ATPase 亞基 SMARCA2 和 SMARCA4 降解劑，也是 PBAF 成員 PBRM1 的降解劑, 對 SMARCA2、SMARCA4 和 PBRM1 作用的 DC50 值分別為 6 nM、11 nM 和 32 nM。ACBI1 由一個 bromodomain 配體、linker 和 E3 泛素連接酶 VHL 構(gòu)成，能誘導(dǎo)抗增殖作用和凋亡。
DC50: 6 nM (SMARCA2), 11 nM (SMARCA4), 32 nM (PBRM1)
ACBI1
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2025/05/22 | HY-128359 | ACBI1
ACBI1 | 2375564-55-7 | 1 mg | 1239元 |
| 2025/05/22 | HY-128359 | ACBI1
ACBI1 | 2375564-55-7 | 5mg | 2900元 |
2375564-55-7, ACBI1 相關(guān)搜索:
- 抑制劑
- 小分子API
- C49H58FN9O7S
- 375564-55-7
- ACBI1 試劑
- ACBI1 試劑
- (2S,4R)-N-(2-(2-(4-((4-(3-氨基-6-(2-羥基苯基)噠嗪-4-基)哌嗪-1-基)甲基)苯氧基)乙氧基)-4-(4-甲基噻唑-5-基)芐基)-1-((S)-2-(1-氟環(huán)丙烷-1-甲酰胺基)-3,3-二甲基丁酰基)-4-羥基吡咯烷-2-甲酰胺
- 化合物ACBI1
- 2375564-55-7
- (2S,4R)-N-(2-(2-(4-((4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide
- N-[(1-Fluorocyclopropyl)carbonyl]-3-methyl-L-valyl-(4R)-N-[2-{2-[4-({4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinyl}methyl)phenoxy]ethoxy}-4-(4-methyl-1,3-thiazol-5-yl)benzyl]-4-hydroxy-L-prolinamide
- PROTACs,anti-proliferative,ACBI 1,Epigenetic Reader Domain,ACBI1,Inhibitor,Apoptosis,inhibit,ACBI-1
- ACBI1