4-[4-[(5S)-5-(氨甲基)-2-羰基-3-唑烷基]苯基]-3-嗎啡啉酮性質(zhì)、用途與生產(chǎn)工藝

應(yīng)用

4-[4-[(5S)-5-(氨甲基)-2-羰基-3-唑烷基]苯基]-3-嗎啡啉酮為制備利伐沙班的中間體，可用作醫(yī)藥合成中間體和有機合成中間體，主要用于實驗室研發(fā)過程和化工醫(yī)藥合成過程中。

制備

S1、將鄰苯二甲酰亞胺鉀鹽(73.4g，0.39mol)加至(S)-4-氯-3-羥基丁腈(39.5g，0.33mol)的DMF(330ml)溶液中，加熱到至70℃反應(yīng)4h，將反應(yīng)液倒至水(440ml)中，攪拌10min，有白色固體析出，抽濾，濾餅減壓干燥，得白色固體(73.6g，97.0％)；mp137～140℃，[α]D25-21.8°(c1，CHCl3)。 S2、將S1步驟得到的(S)-4-(1，3-二氧代異吲哚-2-基)-3-羥基丁腈(63.4g，0.28mol)加至氯仿(330ml)中，冰水浴條件下，加入30％過氧化氫(122ml，3.95mol)、四丁基溴化銨(17.7g，55mmol)和20％氫氧化鈉(110ml，3.36mol)溶液，加畢，升至室溫，攪拌反應(yīng)2h，加入氯仿(110ml)分液，有機相用飽和氯化鈉溶液(220ml×3)洗滌，用無水硫酸鈉干燥，過濾，濾液減壓濃縮得白色固體4-[4-[(5S)-5-(氨甲基)-2-羰基-3-唑烷基]苯基]-3-嗎啡啉酮(65.6g，95.8％)

4-[4-[(5S)-5-(氨甲基)-2-羰基-3-唑烷基]苯基]-3-嗎啡啉酮 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

4-[4-[(5S)-5-(氨甲基)-2-羰基-3-唑烷基]苯基]-3-嗎啡啉酮 生產(chǎn)廠家

 

446292-10-0, 4-[4-[(5S)-5-(氨甲基)-2-羰基-3-唑烷基]苯基]-3-嗎啡啉酮 相關(guān)搜索:

• Intermediates
• Aromatics
• Pharmaceuticals
• Metabolites & Impurities
• Intermediates & Fine Chemicals
• Heterocycles
• Amines
• 其他中間體
• 化工中間體
• 醫(yī)藥原料
• 雜質(zhì)對照品
• 利伐沙班中間體
• 中間體
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• 利伐沙班中間體C
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• 利伐沙班氨基甲基堿雜質(zhì)
• 草胺(利伐沙班雜質(zhì)對照品)
• 4-[4-[(5S)-5-(氨甲基)-2-羰基-3-唑烷基]苯基]-3-嗎啉酮
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• 利伐沙班中間體3
• 4-[4-[(5S)-5-(氨基甲基)-2-氧代-3-惡唑烷基]苯基]-3-嗎啉酮
• 4-[4-[(5S)-5-(氨甲基)-2-氧代-3-噁唑烷基]苯基]-3-嗎啡啉酮
• (S)-4-(4-(5-(氨基甲基)-2-氧代惡唑烷-3-基)苯基)嗎啉-3-酮,利伐沙班中間體 1KG
• 利伐沙班胺
• 立伐沙班中間體C
• 利伐沙班雜質(zhì) 7-1
• 利伐沙班氨甲基雜質(zhì)
• 利伐沙班雜質(zhì)P3D-G
• 4-[4-[(5S)-5-(氨甲基)-2-羰基-3-唑烷基]苯基]-3-嗎啡啉酮
• (S)-4-(4-(5-(氨基甲基)-2-氧代惡唑烷-3-基)苯基)嗎啉-3-酮
• 446292-10-0
• Rivaroxaban Impurity
• TIANFU CHEM----3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]-
• 4-{4-[(5S)-5-aminomethyl)-2-oxo-1,3-oxazolidin-3-yl}morpholin-3-oneQ: What is 4-{4-[(5S)-5-aminomethyl)-2-oxo-1,3-oxazolidin-3-yl}morpholin-3-one Q: What is the CAS Number of 4-{4-[(5S)-5-aminomethyl)-2-oxo-1,3-oxazolidin-3-yl}morpholin-3-one Q: What is the storage condition of 4-{4-[(5S)-5-aminomethyl)-2-oxo-1,3-oxazolidin-3-yl}morpholin-3-one Q: What are the applications of 4-{4-[(5S)-5-aminomethyl)-2-oxo-1,3-oxazolidin-3-yl}morpholin-3-one
• 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}...
• 2-Amino-14-picoline
• Rivaroxaban Impurity B/ Rivaroxaban Aminomethyl Base Impurity
• Rivaroxaban Impurity USP/EP/BP
• 4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one
• Rivaroxaban Aminomethyl Base Impurity
• Rivaroxaban Impurity 9/(S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one
• 4- [4-[(5) -5- (aminomethyl) -2-carbonyl-3-azolidinyl] phenyl] -3-morpholinone
• Rivaroxaban Impurity 7-1
• 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]-
• Rivaroxaban impurity P3D-G
• -4-(4-(5-(Aminomethyl)
• -2-oxooxazolidin-3-yl)
• Rivaroxaban Aminomethyl Impurity
• Rivaroxaban interMediate C
• 4-[4-[(5S)-5-(AMinoMethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-Morpholinone
• 4-{4-[(5S)-5-aminomethyl)-2-oxo-1,3-oxazolidin-3-yl}morpholin-3-on
• 4-{4-[(5S)-5-(aMinoMethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}Morpholin-3-one
• Rivaroxaban Intermediate 3
• Des(5-chloro-2-carboxythienyl) Rivaroxaban
• (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one