米帕林鹽酸鹽
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- CAS號:
- 6151-30-0
- 英文名:
- Mepacrine hydrochloride
- 英文別名:
- mepacrinehcl;hloride2h2-o;QuinacrineHCl;AtabrineMepacnine;ochloride,dihydrate;Mipalin hydrochloride;Quinacrinehydrochlorid;Mepacrine hydrochloride;QUINACRINE,ATABRINE MEPACNINE;atabrinehydrochloridedihydrate
- 中文名:
- 米帕林鹽酸鹽
- 中文別名:
- 米帕林;鹽酸阿伯平;米帕林鹽酸鹽;奎納克林鹽酸鹽;奎納克林二鹽酸鹽二水合物;N4-(6-氯-2-甲氧基-9-吖啶基)-N1,N1-二乙基-1,4-戊二胺二鹽酸鹽二水合物
- CBNumber:
- CB4138653
- 分子式:
- C23H36Cl3N3O3
- 分子量:
- 508.91
- MOL File:
- 6151-30-0.mol
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米帕林鹽酸鹽性質(zhì)、用途與生產(chǎn)工藝
Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) 是一種抗瘧劑 (antimalarial)，在體內(nèi)外均具有抗腫瘤作用。Quinacrine hydrochloride hydrate 抑制 NF-κB 并激活 p53 信號轉(zhuǎn)導(dǎo)，誘導(dǎo)腫瘤細(xì)胞發(fā)生凋亡 (apoptosis)。
Quinacrine (5-20 μM; 24 hours) inhibits the growth of SGC-7901 cells.
Quinacrine (7.5 and 15 μM; 24 hours) induces apoptosis in SGC-7901 cells, which is associated with mitochondria-dependent signal pathway and involves p53 upregulation and caspase-3 activation pathway.
Quinacrine (15 μM; 24 hours) treatment significantly increased the levels of proapoptotic proteins, including cytochrome c, Bax, and p53, and decreased the levels of antiapoptotic protein Bcl-2, thus shifting the ratio of Bax/Bcl-2 in favor of apoptosis .
Cell Viability Assay
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Cell Line:
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SGC-7901 cells
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Concentration:
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0, 5, 10, 15, and 20 μM
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Incubation Time:
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24 hours
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Result:
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Cell viability was inhibited in a dose-dependent manner, and the mean IC
50
value is 16.18 μM.
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Apoptosis Analysis
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Cell Line:
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SGC-7901 cells
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Concentration:
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7.5 and 15 μM
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Incubation Time:
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24 hours
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Result:
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The percentage of apoptotic cells, including the early phase and late phase apoptosis, increased to 26.30%, compared with control group of 3.37%.
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Western Blot Analysis
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Cell Line:
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SGC-7901 cells
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Concentration:
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15 μM
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Incubation Time:
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24 hours
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Result:
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The relative quantity of cytochrome c protein was upregulated, increased from 0.10 to 0.24.
The relative quantity of p53 protein was dramatically increased, from 0.06 to 0.19.
The Bax/Bcl-2 ratio was dramatically elevated from 1.21 to 2.59.
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Quinacrine (100 mg/kg three times per week for two consecutive weeks) significantly suppresses circulating blast cells at days 30/31 and increases the median survival time (MST). Quinacrine does not decrease the body weight of treated animals at the tested dose.
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Animal Model:
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Female SCID mice with acute myeloid leukemia (AML)-PS model
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Dosage:
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100 mg/kg
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Administration:
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Administered by oral gavage (po); three times a week for two consecutive weeks
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Result:
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In the first AML mouse in vivo study, evaluation of circulating leukemic cells detected in blood samples (in percent of white blood cells (WBC)) at day 30/31 showed 72% human tumor cells in the control mice, whereas in mice treated with Quinacrine, this was only 2.2%.
The MST of control mice was 34 days whereas it was 46 days in Quinacrine-treated mice.
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米帕林鹽酸鹽
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價(jià)格 |
|---|
| 2025/02/05 | S5435 | 米帕林鹽酸鹽
Quinacrine Dihydrochloride Dihydrate | 6151-30-0 | 25mg | 794.67元 |
6151-30-0, 米帕林鹽酸鹽 相關(guān)搜索:
- 藥靶配體
- 化學(xué)試劑
- 醫(yī)藥原料
- 醫(yī)藥原料藥-科研原料
- C23H30ClN3O2HCl2H2O
- 69-05-9
- 奎納克林二鹽酸鹽二水合物
- 米帕林
- 鹽酸阿伯平
- 米帕林鹽酸鹽
- 奎納克林鹽酸鹽
- N4-(6-氯-2-甲氧基-9-吖啶基)-N1,N1-二乙基-1,4-戊二胺二鹽酸鹽二水合物
- 6151-30-0
- Mipalin hydrochloride
- Mepacrine hydrochloride USP/EP/BP
- Mepacrine Dihydrochloride Dihydrate
- 1,4-PentanediaMine,N4-(6-chloro-2-Methoxy-9-acridinyl)-N1,N1-diethyl-, hydrochloride, hydrate(1:2:2)
- Quinacrine Hydrochloride (200 mg)
- Quinacrine dihydrochloride dihydrate,97%
- N4-(6-Chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine dihydrochloride dihydrate
- Mepacrine hydrochloride
- QUINACRINE,ATABRINE MEPACNINE
- Quinacrinehydrochlorid
- QuinacrineHCl
- AtabrineMepacnine
- ochloride,dihydrate
- mepacrinehydrochloridedihydrate
- mepacrinehcl
- hloride2h2-o
- atabrinehydrochloridedihydrate
- 6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridinedihydroc
- 6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-acridindihydr
- QUINACRINE HYDROCHLORIDE, DIHYDRATE
- QUINACRINE DIHYDROCHLORIDE DIHYDRATE