175212-04-1
|
|
|
- CAS號:
- 175212-04-1
- 英文名:
- CMI977
- 英文別名:
- LDP977;CMI977;CMI977 (LDP977);1-[4-[(2S,5S)-5-[(4-fluorophenoxy)methyl]oxolan-2-yl]but-3-ynyl]-1-hydroxyurea;Urea, N-[4-[(2S,5S)-5-[(4-fluorophenoxy)methyl]tetrahydro-2-furanyl]-3-butyn-1-yl]-N-hydroxy-
- 中文名:
- 175212-04-1
- 中文別名:
- 化合物 T14986;CMI977 (LDP977)
- CBNumber:
- CB33339641
- 分子式:
- C16H19FN2O4
- 分子量:
- 322.33
- MOL File:
- 175212-04-1.mol
|
|
|
175212-04-1化學性質(zhì)
-
熔點:
-
106-107 °C
-
|
-
沸點:
-
524.8±60.0 °C(Predicted)
-
|
-
密度:
-
1.33±0.1 g/cm3(Predicted)
-
|
-
儲存條件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
酸度系數(shù)(pKa):
-
10.12±0.50(Predicted)
-
|
175212-04-1性質(zhì)、用途與生產(chǎn)工藝
CMI977 是一種有效的 5-Lipoxygenase (5-LO) 抑制劑。
CMI977 is a potent 5-lipoxygenase (5-LO) inhibitor that intervenes in the production of leukotrienes and is presently being developed for the treatment of chronic asthma. It is a single enantiomer with an all-trans (2S,5S) configuration. Of the four isomers of CMI977, the S,S isomer is found to have the best biological activity and is selected for further development.
175212-04-1
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
175212-04-1, 175212-04-1 相關(guān)搜索:
- 抑制劑
- CMI977 (LDP977)
- 化合物 T14986
- 175212-04-1
- CMI977 (LDP977)
- 1-[4-[(2S,5S)-5-[(4-fluorophenoxy)methyl]oxolan-2-yl]but-3-ynyl]-1-hydroxyurea
- Urea, N-[4-[(2S,5S)-5-[(4-fluorophenoxy)methyl]tetrahydro-2-furanyl]-3-butyn-1-yl]-N-hydroxy-
- LDP977
- CMI977