CDK12-IN-3
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- CAS號(hào):
- 2220184-50-7
- 英文名:
- (S)-2-(1-(6-(((6,7-difluoro-1H-benzo[d]imidazol-2-yl)methyl)amino)-9-isopropyl-9H-purin-2-yl)piperidin-2-yl)ethan-1-ol
- 英文別名:
- CMPD 7;CDK12-IN-3;CDK12 inhibitor 3;CDK12IN3,CDK12 IN 3,CDK-12-IN-3;2-Piperidineethanol, 1-[6-[[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]-, (2S)-;(S)-2-(1-(6-(((6,7-difluoro-1H-benzo[d]imidazol-2-yl)methyl)amino)-9-isopropyl-9H-purin-2-yl)piperidin-2-yl)ethan-1-ol
- 中文名:
- CDK12-IN-3
- 中文別名:
- 化合物 T14990;CDK12 抑制劑 3
- CBNumber:
- CB24189000
- 分子式:
- C23H28F2N8O
- 分子量:
- 470.52
- MOL File:
- 2220184-50-7.mol
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CDK12-IN-3化學(xué)性質(zhì)
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沸點(diǎn):
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772.7±70.0 °C(Predicted)
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密度:
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1.51±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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DMSO: 250 mg/mL (531.33 mM)
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形態(tài):
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Solid
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酸度系數(shù)(pKa):
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8.79±0.30(Predicted)
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顏色:
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White to off-white
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CDK12-IN-3性質(zhì)、用途與生產(chǎn)工藝
CDK12-IN-3 是一種有效，選擇性的 CDK12 抑制劑，酶試驗(yàn)中 IC50 值為 491 nM。
CDK12-IN-3 is a highly selective CDK12 inhibitor profiled across a panel of 352 kinases at 0.1 μM. CDK12-IN-3 shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II as well as growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells.
CDK12-IN-3
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2025/02/08 | HY-112261 | CDK12-IN-3 | 2220184-50-7 | 1 mg | 2045元 |
| 2025/02/08 | HY-112261 | CDK12-IN-3
CDK12-IN-3 | 2220184-50-7 | 5mg | 4500元 |
2220184-50-7, CDK12-IN-3 相關(guān)搜索:
- 抑制劑
- C23H28F2N8O
- CDK12 抑制劑 3
- 化合物 T14990
- 2220184-50-7
- CDK12IN3,CDK12 IN 3,CDK-12-IN-3
- 2-Piperidineethanol, 1-[6-[[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]-, (2S)-
- CDK12 inhibitor 3
- CDK12-IN-3
- CMPD 7
- (S)-2-(1-(6-(((6,7-difluoro-1H-benzo[d]imidazol-2-yl)methyl)amino)-9-isopropyl-9H-purin-2-yl)piperidin-2-yl)ethan-1-ol