ω-芋螺毒素 MVIIC
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- CAS號:
- 147794-23-8
- 英文名:
- OMEGA-CONOTOXIN MVIIC
- 英文別名:
- Snx 230;Omega-ctx-mviic;w-ConotoxinMVIIC;OMEGA-CGTX MVIIC;ω-conotoxin mviic;o-Conotoxin MVIIC;OMEGA-CONOTOXIN MVIIC;oMega-Conopeptide M VIIC;CONOTOXIN MVII C (Omega-);w-Conotoxin MVIIC, Conus magus
- 中文名:
- ω-芋螺毒素 MVIIC
- 中文別名:
- 芋螺毒素肽;Ω-芋螺毒素 MVIIC;OMEGA-芋螺毒素 M VIIC;Ω-芋螺毒素MVIIC TFA 鹽;芋螺毒素Ω-CONOTOXIN MVIIC
- CBNumber:
- CB1474567
- 分子式:
- C106H178N40O32S7
- 分子量:
- 2749.25
- MOL File:
- 147794-23-8.mol
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ω-芋螺毒素 MVIIC化學性質(zhì)
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密度:
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1.62±0.1 g/cm3(Predicted)
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儲存條件:
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−20°C
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形態(tài):
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Powder
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水溶解性:
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Soluble to 1 mg/ml in water
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序列:
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H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH2(Disulfide bridge:Cys1-Cys16;Cys8-Cys20;Cys15-Cys26)
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ω-芋螺毒素 MVIIC性質(zhì)、用途與生產(chǎn)工藝
ω-Conotoxin MVIIC 是一種 N 和 P/Q 型鈣通道 (Ca2+ channel) 阻滯劑，可顯著阻斷 11-keto-βboswellic acid 介導的谷氨酸釋放抑制。
多肽
ω-芋螺毒素 MVIIC（芋螺毒素肽）是具有抑制撲入哺乳動物中樞神經(jīng)系統(tǒng)中的其他鈣離子亞型通道的多肽，序列由26個氨基酸組成，序列中的6個Cys形成了三對二硫鍵，多肽結構相當穩(wěn)定。這種多肽序列中有四個Lys，但由于β-折疊的存在，導致側鏈基團被包裹在序列中，因此多肽對生物素化的反應性很多，對生物活性的影響較小，因此芋螺毒素肽具有成為藥物原料的潛能非常巨大。
參考質(zhì)量標準
外觀:白色粉末
純度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
內(nèi)毒素≤50EU/mg
氨基酸組成分析≤±10%
ω-芋螺毒素 MVIIC
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
147794-23-8, ω-芋螺毒素 MVIIC 相關搜索:
- Voltage-gated Ion Channels
- Toxins and Venoms
- Snail
- Peptide ToxinsPeptides for Cell Biology
- Peptide ToxinsCell Signaling and Neuroscience
- Ion Channel Modulating Peptides
- Calcium Channel Modulators
- Ion Channels
- Calcium channel
- 藥靶配體
- 目錄肽
- 多肽
- 優(yōu)勢產(chǎn)品
- 美容多肽
- 標準品
- Cell Signaling and Neuroscience
- Cell Biology
- Calcium Channel Modulators
- BioChemical
- Voltage-gated Ion Channels
- Ion Channels
- Peptide Toxins
- C106H178N40O32S7
- Ω-芋螺毒素MVIIC TFA 鹽
- 芋螺毒素Ω-CONOTOXIN MVIIC
- 芋螺毒素肽
- Ω-芋螺毒素 MVIIC
- OMEGA-芋螺毒素 M VIIC
- 147794-23-8
- omega-Conotoxin MVIIC TFA salt
- L-Cysteinamide, L-cysteinyl-L-lysylglycyl-L-lysylglycyl-L-alanyl-L-prolyl-L-cysteinyl-L-arginyl-L-lysyl-L-threonyl-L-methionyl-L-tyrosyl-L-α-aspartyl-L-cysteinyl-L-cysteinyl-L-serylglycyl-L-seryl-L-cysteinylglycyl-L-arginyl-L-arginylglycyl-L-lysyl-, cyclic (1→16),(8→20),(15→26)-tris(disulfide)
- 2-[(1R,4S,7S,10S,13S,16S,19S,22R,27R,30S,36S,39S,45R,48S,54S,57R,62R,65S,71S,77S,83S)-62-amino-7,30,65,71-tetrakis(4-aminobutyl)-4,36,39-tris(3-carbamimidamidopropyl)-27-carbamoyl-10-[(1R)-1-hydroxyethyl]-48,54-bis(hydroxymethyl)-16-[(4-hydroxyphenyl)methyl]-77-methyl-13-(2-methylsulfanylethyl)-2,5,8,11,14,17,20,29,32,35,38,41,44,47,50,53,56,63,66,69,72,75,78,84,91-pentacosaoxo-24,25,59,60,87,88-hexathia-3,6,9,12,15,18,21,28,31,34,37,40,43,46,49,52,55,64,67,70,73,76,79,85,90-pentacosazatetracyclo[43.40.4.2^{22,57}.0^{79,83}]hennonacontan-19-yl]acetic acid
- H-CYS-LYS-GLY-LYS-GLY-ALA-PRO-CYS-ARG-LYS-THR-MET-TYR-ASP-CYS-CYS-SER-GLY-SER-CYS-GLY-ARG-ARG-GLY-LYS-CYS-NH2 (DISULFIDE BRIDGE: 1-16, 8-20, AND 15-26)
- H-CYS-LYS-GLY-LYS-GLY-ALA-PRO-CYS-ARG-LYS-THR-MET-TYR-ASP-CYS-CYS-SER-GLY-SER-CYS-GLY-ARG-ARG-GLY-LYS-CYS-NH2
- OMEGA-CONOTOXIN MVIIC, CONUS MAGUS
- OMEGA-CONOTOXIN MVIIC
- OMEGA-CGTX MVIIC
- CONOTOXIN MVII C (Omega-)
- ω-Conotoxin MVIIC|OMEGA-CONOTOXIN MVIIC
- o-Conotoxin MVIIC
- oMega-Conopeptide M VIIC
- Snx 230
- Omega-ctx-mviic
- Omega-conotoxin m viia (reduced), 7-L-proline-9-L-arginine-10-L-lysine-11-L-threonine-17-L-serine-20A-endo-glycine-22-L-arginine-, cycli (1-16),(8-20),(15-25)-tris(disulfide)
- M.W. 2749.70 C106H178N40O32S7
- ω-conotoxin mviic
- w-ConotoxinMVIIC
- w-Conotoxin MVIIC, Conus magus
- CKGKGAPCRKTMYDCCSGSCGRRGKC-NH2 (DISULFIDE BRIDGE: 1-16,8-20 AND 15-26)
- CYS-LYS-GLY-LYS-GLY-ALA-PRO-CYS-ARG-LYS-THR-MET-TYR-ASP-CYS-CYS-SER-GLY-SER-CYS-GLY-ARG-ARG-GLY-LYS-CYS-NH2