960527-22-4
中文名稱
N-(4-fluorobenzyl)-5-isobutyl-2,2'-bithiazole-4-carboxamide
英文名稱
N-(4-fluorobenzyl)-5-isobutyl-2,2'-bithiazole-4-carboxamide
CAS
960527-22-4
分子式
C18H18FN3OS2
分子量
375.48
MOL 文件
960527-22-4.mol

基本信息
中文別名
化合物 T27634 英文別名
NZ-4W-28-F
W 28 F
Isothiafludine (NZ-4)
N-(4-fluorobenzyl)-5-isobutyl-2,2'-bithiazole-4-carboxamide
物理化學(xué)性質(zhì)
密度1.287±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)13.06±0.46(Predicted)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
Isothiafludine, also NZ-4 and W-28-F, is a HBV virus inhibitor that dramatically reduces the HBV DNA level in cells. During the hepatitis B virus (HBV) life cycle, nucleocapsid assembly is essential for HBV replication. Both RNA reverse transcription and DNA replication occur within the HBV nucleocapsid. HBV nucleocapsid is consisted of core protein (HBcAg), whose carboxy-terminal domain (CTD) contains an Arg-rich domain (ARD). The ARD of HBcAg does contribute to the encapsidation of pregenomic RNA (pgRNA).