941987-60-6
中文名稱
H-151
英文名稱
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
CAS
941987-60-6
分子式
C17H17N3O
分子量
279.34
MOL 文件
941987-60-6.mol
更新日期
2025/03/25 01:14:20
941987-60-6 結(jié)構(gòu)式
基本信息
中文別名
1-(4-乙基苯基)-3-(1H-吲哚-3-基)脲 英文別名
H-151H 151 NEW
STING inhibitor
STING antagonist
N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea
H151
H-151
H-151
H-151
STING ANTAGONIST
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
Urea, N-(4-ethylphenyl)-N'-1H-indol-3-yl-
物理化學(xué)性質(zhì)
沸點(diǎn)399.9±25.0 °C(Predicted)
密度1.298±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,Room Temperature
溶解度溶于 DMSO (25 mg/ml)
酸度系數(shù)(pKa)14.96±0.70(Predicted)
形態(tài)固體
顏色米白色
穩(wěn)定性可在-20°C下的DMSO中的溶液儲(chǔ)存長(zhǎng)達(dá)3個(gè)月。
H-151價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/02/08 | HY-112693 | H-151 H-151 | 941987-60-6 | 5 mg | 800元 |
| 2025/02/08 | HY-112693 | H-151 H-151 | 941987-60-6 | 10mM * 1mLin DMSO | 880元 |
| 2025/02/08 | HY-112693 | H-151 H-151 | 941987-60-6 | 10mg | 1200元 |
常見(jiàn)問(wèn)題列表
生物活性
H-151是STING的共價(jià)拮抗劑，在人細(xì)胞和體內(nèi)均具有顯著的抑制活性。靶點(diǎn)
| Target | Value |
|
STING
() |
體外研究
H-151 (0.02-2 μM) reduces IFNβ luciferase reporter measurements of HEK293T cells.
H-151 (0.5 μM; 2 h) inhibits the phosphorylation of TBK1 in THP-1 cells.
H-151 (1 μM; 3 h) suppresses hsSTING palmitoylation.
體內(nèi)研究
H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice.
H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in
Trex1
?/?
mice that expressed a bioluminescent IFNβ reporter.
H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice.