880546-17-8
中文名稱
化合物 T27708
英文名稱
L-Phenylalaninamide, N-[[[1-[(2,6-dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)-1H-indol-5-yl]amino]carbonyl]glycyl-L-lysyl-N-(diphenylmethyl)-
CAS
880546-17-8
分子式
C51H56Cl2N8O4
分子量
915.95
MOL 文件
880546-17-8.mol
880546-17-8 結(jié)構(gòu)式
基本信息
中文別名
化合物 T27708 英文別名
K14585K-14585
K 14585
L-Phenylalaninamide, N-[[[1-[(2,6-dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)-1H-indol-5-yl]amino]carbonyl]glycyl-L-lysyl-N-(diphenylmethyl)-
物理化學性質(zhì)
沸點1115.5±65.0 °C(Predicted)
密度1.30±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)12.35±0.46(Predicted)
應(yīng)用領(lǐng)域
用途一
K-14585 is a proteinase-activated receptor 2 antagonist. Pretreatment with K-14585 inhibited PAR(2)-mediated p65 NFkappaB phosphorylation and NFkappaB-DNA binding. K-14585 inhibited SLIGKV-stimulated IL-8 production, but given alone increased IL-8. K-14585 antagonized PAR(2) competitively, resulting in inhibition of PAR(2)-mediated signalling and physiological responses both in vitro and in vivo. K-14585 could be useful in evaluating PAR(2)-mediated biological events and might lead to a new generation of therapeutically useful antagonists.