871037-95-5
871037-95-5 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)770.4±60.0 °C(Predicted)
密度1.68±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)14.18±0.60(Predicted)
應(yīng)用領(lǐng)域
用途一
TTT-3002 is a tyrosine kinase inhibitor (TKI) that is one of the most potent FLT3 inhibitors discovered to date. Studies using human FLT3/ITD mutant leukemia cell lines revealed the half maximal inhibitory concentration (IC50) for inhibiting FLT3 autophosphorylation is from 100 to 250 pM. The proliferation IC50 for TTT-3002 in these same cells was from 490 to 920 pM. TTT-3002 also showed potent activity when tested against the most frequently occurring FLT3-activating point mutation, FLT3/D835Y, against which many current TKIs are ineffective.