869650-21-5
中文名稱
化合物 T27704
英文名稱
Ethanone, 1-[3-[6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]-
CAS
869650-21-5
分子式
C18H18N4O
分子量
306.36
MOL 文件
869650-21-5.mol
869650-21-5 結構式
基本信息
中文別名
化合物 T27704 英文別名
K00135K-00135
K 00135
Ethanone, 1-[3-[6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]-
應用領域
用途一
K00135 is a potent and selective inhibitor of PIM kinases. K00135 was shown to impair survival and clonogenic growth of a panel of human acute leukemia cells. Exposure to K00135 also significantly suppressed in vitro growth of leukemic blasts from five acute myelogenous leukemia patients but not of normal umbilical cord blood mononuclear cells.