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863598-09-8

中文名稱 863598-09-8
英文名稱 Casein Kinase II Inhibitor IV
CAS 863598-09-8
分子式 C24H23N5O3
分子量 429.47
MOL 文件 863598-09-8.mol
更新日期 2024/11/19 11:42:47
863598-09-8 結(jié)構(gòu)式 863598-09-8 結(jié)構(gòu)式

基本信息

中文別名
化合物CASEIN KINASE II INHIBITOR IV
英文別名
CK2-IN-1
Casein Kinase II Inhibitor IV
3-[2-[(3,4,5-Trimethoxyphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]benzenepropanenitrile
Benzenepropanenitrile, 3-[2-[(3,4,5-trimethoxyphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-

物理化學(xué)性質(zhì)

沸點(diǎn)605.0±65.0 °C(Predicted)
密度1.25±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : ≥ 250 mg/mL (582.11 mM)
酸度系數(shù)(pKa)6.44±0.30(Predicted)
形態(tài)Solid
顏色Light yellow to yellow

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
863598-09-8價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/02/08HY-111378Casein Kinase II Inhibitor IV863598-09-81 mg748元
2025/02/08HY-111378863598-09-8
Casein Kinase II Inhibitor IV
863598-09-810mM * 1mLin DMSO2044元
2025/02/08HY-111378863598-09-8
Casein Kinase II Inhibitor IV
863598-09-85mg2163元

常見問題列表

生物活性
Casein Kinase II Inhibitor IV是表皮角質(zhì)形成細(xì)胞分化的小分子誘導(dǎo)劑。
靶點(diǎn)

Target: Casein Kinase

體外研究

Treatment of human epidermal keratinocytes (NHEKs) with Casein Kinase II Inhibitor IV leads to an increase in the early differentiation markers keratins 1 and 10 at 48 h. Increased levels of IVL and TGM are observed in cells treated with Casein Kinase II Inhibitor IV at 72 h and persisted at 96 h. In addition, treated with Casein Kinase II Inhibitor IV expressesloricrin, a terminal differentiation marker, at later time points. Similar results are observed by messenger RNA (mRNA) expression analysis of NHEKs treated with Casein Kinase II Inhibitor IV. At early time points (12 and 24 h), treatment with Casein Kinase II Inhibitor IV leads to the upregulation of keratinocyte early differentiation marker genes, including keratin 1 (5.4-fold) and keratin 10 (5.4-fold). Terminal differentiation marker genes, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), are upregulated at late time points (36 and 48 h). These results are again consistent with the ability of Casein Kinase II Inhibitor IV to induce differentiation of epidermal progenitor cells into terminally differentiated keratinocytes.

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