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80809-81-0

中文名稱 多西苯醌
英文名稱 AA-861
CAS 80809-81-0
分子式 C21H26O3
分子量 326.43
MOL 文件 80809-81-0.mol
80809-81-0 結(jié)構(gòu)式 80809-81-0 結(jié)構(gòu)式

基本信息

中文別名
多西苯醌
2-(12-羥基十二-5,10-二基)-3,5,6-三甲基對(duì)苯醌
英文別名
AA-861
Decebenone
docebenone
AA-861 (Docebenone)
2-[12-HYDROXYDODECA-5,10-DIYNYL]-3,5,6-TRIMETHYL-P-BENZOQUINONE
2-(12-Hydroxydodecane-5,10-diynyl)-3,5,6-trimethyl-p-benzoquinone
2-(12-Hydroxy-5,10-dodecadiynyl)-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dione
2-(12-hydroxydodeca-5,10-diynyl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione
2,5-Cyclohexadiene-1,4-dione, 2-(12-hydroxy-5,10-dodecadiyn-1-yl)-3,5,6-trimethyl-

物理化學(xué)性質(zhì)

儲(chǔ)存條件2-8°C
溶解度ethanol:
形態(tài)固體
顏色Light yellow to yellow

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS05
警示詞危險(xiǎn)
危險(xiǎn)性描述H314-H318
防范說(shuō)明P280-P305+P351+P338-P310
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類別碼36/37/38
安全說(shuō)明26-36
WGK Germany3
多西苯醌價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/05/22HY-12886多西苯醌
Docebenone
80809-81-01 mg997元
2025/05/22HY-12886多西苯醌
Docebenone
80809-81-05mg3490元
2025/05/22HY-12886多西苯醌
Docebenone
80809-81-010mM * 1mLin DMSO4400元

常見(jiàn)問(wèn)題列表

生物活性
Docebenone (AA 861) 是一種有效的、選擇性的和有口服活性的 5-脂氧合酶 (5-LO) 抑制劑。
靶點(diǎn)

5-LO

體外研究

Treatment of trichomonads with the 5-LO inhibitor Docebenone, significantly inhibits the ability of trichomonads to secrete LTB 4 compared to results for trichomonads treated with medium. Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production. Docebenone at 10-200 μM increases [Ca 2+ ] i concentration dependently.

體內(nèi)研究

Docebenone might protect experimental acute necrotizing pancreatitis in rats. Docebenone suppresses the release of SRS-A by 55-97%, dose-dependently in doses of 10 -8 -10 -5 M in monkeys. The antigen-induced SRS-A release from these fragments is dose dependently inhibited by 25-93% of Docebenone, with doses of 10 -8 -10 -5 M.

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