580-74-5
580-74-5 結(jié)構(gòu)式
基本信息
中文別名
占托西林黃青霉素
青黴黃素X
英文別名
BrevicidNsc179485
Brevicide
Trianthil
Brevicide-x
Xantocillin
Ophthocillin
XANTHOCILINX
XANTHOCILLINX
Ethylene isocyanide, bis(p-hydroxybenzylidene)-
常見(jiàn)問(wèn)題列表
生物活性
Xanthocillin 是從青霉中提取的一種海洋藥劑，通過(guò)抑制 MEK/ERK 途徑誘導(dǎo)自噬。體外研究
Xantocillin (SD118-xanthocillin X (1)) (6.9-55.56 μM; 48 hours) has a significant inhibitory effect on the proliferation of HepG2 cells with an IC
50
of 22.88 ± 4.76 μM.
Xantocillin (SD118-xanthocillin X (1)) (24.3 μM; 12-48 hours) increases the expression of the autophagy-related genes, LC3, and Beclin 1.
Cell Proliferation Assay
| Cell Line: | HepG2 cells |
| Concentration: | 6.9 μM, 13.89 μM, 27.78 μM, 55.56 μM |
| Incubation Time: | 48 hours |
| Result: | A concentration-dependent inhibitory effect on cellular growth in the HepG2 cells with the IC 50 of 22.88 ± 4.76 μM. |
Western Blot Analysis
| Cell Line: | HepG2 cells |
| Concentration: | 24.3 μM |
| Incubation Time: | 12 hours, 24 hours, 48 hours |
| Result: | Increased the expression of the autophagy-related genes, LC3, and Beclin 1. |