53342-16-8
53342-16-8 結(jié)構(gòu)式
基本信息
中文別名
環(huán)[2-甲基丙氨酰-L-苯丙氨酰-D-脯氨酰-(ALPHAS,2S)-ALPHA-氨基-H-氧代-2-環(huán)氧乙烷辛酰 英文別名
SL-3440CHLAMYDOCIN
Antibiotic SL-3440
2-Methylcyclo[Ala-L-Phe-D-Pro-6-[(S)-2-oxo-2-oxiranylethyl]-L-Nle-]
Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl]
Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl]
物理化學(xué)性質(zhì)
沸點(diǎn)861.8±65.0 °C(Predicted)
密度1.27±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: soluble; Ethanol: soluble; Methanol: soluble
酸度系數(shù)(pKa)13.36±0.70(Predicted)
形態(tài)固體
安全數(shù)據(jù)
常見(jiàn)問(wèn)題列表
生物活性
Chlamydocin，一種真菌代謝產(chǎn)物，是一種高效的 HDAC 抑制劑，IC50 為 1.3 nM。Chlamydocin 具有很強(qiáng)的抗增殖和抗癌活性。Chlamydocin 通過(guò)激活 caspase-3 誘導(dǎo)細(xì)胞凋亡。靶點(diǎn)
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HDAC 1.3 nM (IC 50 ) |
體外研究
Chlamydocin is originally isolated from the fungus Diheterospora chlamydosporia . Chlamydocin exhibits a broad spectrum of antiproliferative activity toward various cancer cell lines, irrespective of their p53 status. The antiproliferative activity of Chlamydocin is accompanied by accumulation of hyperacetylated histones H3 and H4, induction of p21cip1/waf1, and accumulation of cells in G2/M phase of the cell cycle.