509-15-9
509-15-9 結構式
基本信息
胡曼鹼
鉤吻堿
鉤吻寧
鉤吻堿鉀
鉤吻素甲
鉤吻素堿
鉤吻堿甲
常綠黃素馨堿
鉤吻堿對照品,
GESEMINE
GELSAMINE
GELSEMINE
gelsemine free base
3h)indol)-2’(1’,h)-one
8abeta,9s*,10s*))-8alph
Gelsemine, 98%, from Gelsemium elegans (Gardner & Chapm.) Benth.
ne,5-ethenyl-3,4,4a,5,6,7,8,8a-octahydro-7-methyl-,(3r-(3alpha,4abeta,5alpha,
spiro(3,5,8-ethanylylidene-1h-pyrano(3,4-c)pyridine-10,3’-(3h)indol)-2’(1’h)-o
物理化學性質
安全數據
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2025/05/22 | HY-N0388 | 鉤吻堿 Gelsemine | 509-15-9 | 5mg | 600元 |
| 2025/05/22 | HY-N0388 | 鉤吻堿 Gelsemine | 509-15-9 | 10mM * 1mLin DMSO | 660元 |
| 2025/05/22 | HY-N0388 | 鉤吻堿 Gelsemine | 509-15-9 | 10mg | 960元 |
常見問題列表
Gelsemine is an effective agent for treatment of both neuropathic pain and sleep disturbance in partial sciatic nerve ligation (PSNL) mice. Gelsemine (4 mg/kg) exerts analgesic effects on PSNL-induced mechanical allodynia and thermal hyperalgesia. In PSNL mice, Gelsemine (2 and 4 mg/kg) increases the mechanical threshold for 4 h and prolonged the thermal latencies for 3 h. Furthermore, Gelsemine (4 mg/kg, administered at 6:30 AM) increases non-rapid eye movement (non-REM, NREM) sleep, decreases wakefulness, but does not affect rapid eye movement (REM) sleep during the first 3 h in PSNL mice.
Immunohistochemical study shows that PSNL increases c-Fos expression in the neurons of the anterior cingulate cortex, and Gelsemine (4 mg/kg) decreases c-Fos expression by 58%.