42422-68-4
中文名稱
B-赤霉醇
英文名稱
BETA-ZEARALANOL
CAS
42422-68-4
分子式
C18H26O5
分子量
322.4
MOL 文件
42422-68-4.mol
更新日期
2025/03/11 08:03:23
42422-68-4 結(jié)構(gòu)式
基本信息
中文別名
B-赤霉醇Β-玉米赤霉醇
-ZEARALANOL
英文別名
P-1560taleranol
β-Zeranol
BETAZERANOL
B-zearalanol
β-Zearalanol
BETA-ZEARALANOL
Zearalanol, beta-
P-1560【pharmaceutical】
Taleranol (β-Zearalanol)
所屬類別
分析化學(xué)：食品和化妝品標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
熔點134-137°C
沸點576.0±50.0 °C(Predicted)
密度1.153±0.06 g/cm3(Predicted)
閃點2℃
儲存條件2-8°C
溶解度Methanol: 10 mg/ml
酸度系數(shù)(pKa)8.08±0.60(Predicted)
形態(tài)固體
顏色White to off-white
BRN4844761
B-赤霉醇價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-N6740 | B-赤霉醇 Beta-Zearalanol | 42422-68-4 | 5mg | 1600元 |
| 2025/02/08 | HY-N6740 | B-赤霉醇 Beta-Zearalanol | 42422-68-4 | 10 mM * 1 mLin DMSO | 1760元 |
| 2025/02/08 | HY-N6740 | B-赤霉醇 Beta-Zearalanol | 42422-68-4 | 10mg | 2600元 |
常見問題列表
生物活性
Beta-Zearalanol 是由鐮刀菌屬 Fusarium 產(chǎn)生的一種霉菌毒素，可以在哺乳動物生殖細(xì)胞中引起細(xì)胞凋亡 (apoptosis) 和氧化應(yīng)激反應(yīng)。 Beta-Zearalanol 是玉米赤霉烯酮（ZEA）的衍生物，可以與葡萄糖醛酸 (glucuronic acid) 結(jié)合。體外研究
βeta-Zearalenol (0-200 μM; 24 hours) inhibits BGC proliferation in a dose-dependent manner, with an IC 50 of 25 μM. βeta-Zearalenol (0-100 μM; 72 hours) shows high toxic with an IC 50 of 15.2 μM in the HepG2 cells, synergistic effect of β-ZOL+ZEN or β-ZOL+α-ZOL with IC 50 values of 19.8 uM, 16.8 uM, respectively. βeta-Zearalenol (0-10 μM; 72 hours) has the highest inhibition effect on the all three investigated cytokines: IL-8, IL-1β and TNF-α by comparation with ZEA or α-Zearalenol.
Cell Viability Assay
| Cell Line: | HepG2 cells |
| Concentration: | 0-100 μM |
| Incubation Time: | 72 hours |
| Result: | Shown a dose-dependent reduction of viability of cells treated with Beta-Zearalanol. |
Cell Proliferation Assay
| Cell Line: | BGC cells |
| Concentration: | 0 μM, 5 μM, 10 μM, 15 μM, 25 μM, 50 μM, 100 μM, and 200 μM |
| Incubation Time: | 24?hours |
| Result: | Inhibited cell proliferation in a dose-dependent manner. |
RT-PCR
| Cell Line: | HepG2 cells |
| Concentration: | 1 μM, 5 μM, 10 μM |
| Incubation Time: | 72 hours |
| Result: | Had the higher cytotoxic effect in comparation with α-Zearalenol. |