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374703-78-3

中文名稱(chēng) 374703-78-3
英文名稱(chēng) PKG drug G1
CAS 374703-78-3
分子式 C13H11N3OS
分子量 257.31
MOL 文件 374703-78-3.mol
更新日期 2025/01/23 13:36:08
374703-78-3 結(jié)構(gòu)式 374703-78-3 結(jié)構(gòu)式

基本信息

中文別名
化合物PKG DRUG G1
英文別名
PKG drug G1
4-Imidazolidinone, 5-[(2-methyl-1H-indol-3-yl)methylene]-2-thioxo-

物理化學(xué)性質(zhì)

密度1.45±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): Partially soluble
酸度系數(shù)(pKa)6.71±0.20(Predicted)
形態(tài)結(jié)晶固體
顏色Light brown to reddish brown
374703-78-3價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2025/05/22HY-112197374703-78-3
PKG drug G1
374703-78-35mg622元
2025/05/22HY-112197374703-78-3
PKG drug G1
374703-78-310mM * 1mLin DMSO684元
2025/05/22HY-112197374703-78-3
PKG drug G1
374703-78-310mg952元

常見(jiàn)問(wèn)題列表

生物活性
PKG drug G1 是靶向C42的 Protein Kinase G Iα (PKG Iα) 的激活劑,可導(dǎo)致血管舒張和血壓下降。
靶點(diǎn)
TargetValue
PKG Iα
()
體內(nèi)研究

PKG drug G1 induces vasodilation of isolated resistance blood vessels and blood pressure lowering in a mouse model of angiotensin II–induced hypertension. PKG drug G1 efficiently relaxes WT but not knockin (KI) vessels, which is then assessed in a murine model of hypertension. PKG drug G1 lowers blood pressure in hypertensive WT, but not KI, mice in vivo. PKG drug G1 is tested in vivo in healthy mice implanted with telemetric devices that allow blood pressure and heart rate to be constantly monitored. PKG drug G1 or vehicle control is administrated by intraperitoneal injection, and the acute impact on hemodynamics assessed. PKG drug G1 administered at 7.4 mg/kg does not decrease blood pressure, but there is a concomitant reflex tachycardia. When this is repeated using 14.8 mg/kg dose of PKG drug G1, again blood pressure is not altered-but this higher dose induces a potentiated increase in heart rate.

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