2253744-57-7
英文名稱(chēng)
1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-, hydrochloride (1:1)
CAS
2253744-57-7
分子式
C20H21Cl3N8O3
分子量
527.79
MOL 文件
2253744-57-7.mol
2253744-57-7 結(jié)構(gòu)式
基本信息
英文別名
1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-, hydrochloride (1:1)應(yīng)用領(lǐng)域
用途一
TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells.