2187412-79-7
中文名稱(chēng)
DI-404
英文名稱(chēng)
DI-404
CAS
2187412-79-7
分子式
C35H45ClN6O6S
分子量
713.29
MOL 文件
2187412-79-7.mol
2187412-79-7 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)1023.6±65.0 °C(Predicted)
密度1.34±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)13.20±0.46(Predicted)
應(yīng)用領(lǐng)域
用途一
DI-404 is a high-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction (Kd= 6.9 nM). DI-404 effectively and selectively inhibits the neddylation of cullin 3 over other cullin members. Further optimization of DI-404 may yield a new class of therapeutics for the treatment of human diseases in which cullin 3 CRL plays a key role.