2089647-47-0
中文名稱(chēng)
化合物SGN-2FF
英文名稱(chēng)
SGN-2FF
CAS
2089647-47-0
分子式
C6H11FO4
分子量
166.15
MOL 文件
2089647-47-0.mol
更新日期
2024/12/13 09:52:59
2089647-47-0 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)323.7±42.0 °C(Predicted)
密度1.42±0.1 g/cm3(Predicted)
儲(chǔ)存條件Store at -20°C,protect from light
酸度系數(shù)(pKa)11?+-.0.70(Predicted)
形態(tài)Solid
顏色White to off-white
水溶解性Water : 36.67 mg/mL (220.70 mM)
常見(jiàn)問(wèn)題列表
生物活性
SGN-2FF 是一種有效的，具有口服活性的巖藻糖基化抑制劑，抑制巖藻糖基轉(zhuǎn)移酶 (fucosyltransferase) 的活性，具有抗腫瘤活性。靶點(diǎn)
Fucosyltransferase
體外研究
SGN-2FF (2-Fluorofucose) is an inhibitor of fucosylation, inhibits cellular fucosylation by depleting the fucosylation substrate GDP-fucose, and by direct inhibition of fucosyltransferases, and leads to the production of afucosylated glycoproteins including antibodies. SGN-2FF activates human T cells in an antigen-dependent manner.
體內(nèi)研究
SGN-2FF exhibits antitumor activity in multiple mouse tumor models, showing substantial tumor growth delay. SGN-2FF elevates the protective effect of a lymphoma vaccine in a syngeneic mouse model.