205678-26-8
205678-26-8 結(jié)構(gòu)式
基本信息
化合物 SB-267268
1H-2-Benzazepine-4-acetic acid, 2,3,4,5-tetrahydro-3-oxo-8-[3-(2-pyridinylamino)propoxy]-2-(2,2,2-trifluoroethyl)-, (4S)-
物理化學(xué)性質(zhì)
常見問題列表
SB-267268 was much less potent for inhibition of human, mouse, and ratαvβ6 integrin. SB-267268 inhibits the attachment of bothαvβ3-transfected HEK293 cells to microtiter plate wells precoated with arginine-glycine-aspartic acid (RGD)-containing matrix proteins with IC 50 values of 12 nM. SB-267268 also inhibits vitronectin-mediated human and rat aortic smooth-muscle-cell (SMC) migration with IC 50 values of approximately 12.3 nM and 3.6 nM, respectively.
SB-267268 (60 mg/kg; bi-daily, i.p.) reduces blood vessel profiles (BVPs) in the inner retina by 50%.
In ROP mice treated with SB-267268, VEGF and VEGFR-2 gene expression in the inner nuclear layer (INL) and the ganglion cell layer (GCL) is reduced.
| Animal Model: | Pregnant female C57BL/6 mice (ROP mice) |
| Dosage: | 60 mg/kg |
| Administration: | I.p.; bi-daily |
| Result: | Reduced blood vessel profiles (BVPs) in the inner retina by 50%. |