195733-43-8
195733-43-8 結(jié)構(gòu)式
基本信息
阿曲生坦鹽酸鹽
(2R,3R,4S)-4-(1,3-苯并二氧戊環(huán)-5-基)-1-[2-(二丁基氨基)-2-氧代乙基]-2-(4-甲氧基苯基)吡咯烷-3-羧酸鹽酸鹽
ABT 627
ABT-627
A 147627.1
Abbott 147627
Atrasentan HCl
Unii-E4G31X93za
ABT-627 hydrochloride
A-147627 hydrochloride
Atrasentan hydrochloride
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-15403A | 鹽酸阿曲生坦 Atrasentan hydrochloride | 195733-43-8 | 1 mg | 496元 |
| 2025/02/08 | HY-15403A | (2R,3R,4S)-4-(1,3-苯并二氧戊環(huán)-5-基)-1-[2-(二丁基氨基)-2-氧代乙基]-2-(4-甲氧基苯基)吡咯烷-3-羧酸鹽酸鹽 Atrasentan hydrochloride | 195733-43-8 | 5mg | 1184元 |
| 2025/02/08 | HY-15403A | (2R,3R,4S)-4-(1,3-苯并二氧戊環(huán)-5-基)-1-[2-(二丁基氨基)-2-氧代乙基]-2-(4-甲氧基苯基)吡咯烷-3-羧酸鹽酸鹽 Atrasentan hydrochloride | 195733-43-8 | 10mM * 1mLin DMSO | 1425元 |
常見問題列表
IC50: 0.055 nM (ET A )
Atrasentan hydrochloride (ABT-627 hydrochloride) (0-50 μM) significantly inhibits LNCaP and C4-2b prostate cancer cell growth. Atrasentan profoundly induces several CYPs and drug transporters (e.g. 12-fold induction of CYP3A4 at 50 μM). It is a moderate P-gp inhibitor (IC 50 in P388/dx cells=15.1±1.6 μM) and a weak BCRP inhibitor (IC 50 in MDCKII-BCRP cells=59.8±11 μM).
Atrasentan hydrochloride (ABT-627 hydrochloride) (3 mg/kg, p.o.) inhibits the pressor response induced by big endothelin-1 (1 nmol/kg) in pithed rats. Aatrasentan (ABT-627, 10 mg/kg, i.p.) inhibits the C4-2b tumor growth within the bone environment to some extent in the SCID-hu model.