186392-65-4
186392-65-4 結(jié)構(gòu)式
基本信息
CP296
CP-296
CP 296
CPD2802
GPi 296
CP368296
CP-368296
CP 368296
Ingliforib
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/05/22 | HY-19396 | Ingliforib | 186392-65-4 | 1 mg | 1000元 |
| 2025/05/22 | HY-19396 | CPD2802 Ingliforib | 186392-65-4 | 5mg | 2000元 |
| 2025/05/22 | HY-19396 | CPD2802 Ingliforib | 186392-65-4 | 10mM * 1mLin DMSO | 2015元 |
常見問題列表
IC50: 52 nM (liver Glycogen phosphorylase), 352 nM (Muscle Glycogen phosphorylase), 150 nM (Barin Glycogen phosphorylase)
Ingliforib is a glycogen phosphorylase inhibitor, and inhibits the myocardial GP isoforms (muscle and brain) with IC 50 s of 352 and 150 nM, respectively, also a potent inhibitor of the liver isoform (IC 50 of 52 nM). Ingliforib (0.1, 1, 10 μM) dose-dependently reduces infarct size in the isolated rabbit hearts.
Ingliforib (15 mg/kg) potently reduces infarct size by 52%, and decreases plasma glucose and lactate concentrations in openchest anesthetized rabbits. Ingliforib (15 mg/kg) also inhibits myocardial glycogen phosphorylase a (GPa) and total glycogen phosphorylase (GP) activity in anesthetized rabbits.